EPH Receptor B4 Protein (EPHB4) (AA 563-987) (His-GST)

Produktnummer ABIN7317112

Dieses Recombinant EPH Receptor B4-Protein wird in Baculovirus infected Insect Cells exprimiert.

Kurzübersicht für EPH Receptor B4 Protein (EPHB4) (AA 563-987) (His-GST) (ABIN7317112)

Target: EPH Receptor B4 (EPHB4)

Protein-Typ: Recombinant

Biologische Aktivität: Active

Spezies: Human

Quelle: Baculovirus infected Insect Cells

Reinheit: > 90 % as determined by reducing SDS-PAGE.

Produktdetails

Proteineigenschaft: AA 563-987

Aufreinigungstag / Konjugat: Dieses EPH Receptor B4 Protein ist gelabelt mit His-GST.

Verwendungszweck: Recombinant Human EphB4/HTK Protein (aa 563-987, His & GST Tag)

Sequenz: Leu563-Tyr987

Produktmerkmale: A DNA sequence encoding the human EPHB4 (P54760) (Leu563-Tyr987) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.

Sterilität: 0.2 μm filtered

Endotoxin-Niveau: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: The specific activity was determined to be 47 nmol/min/mg using Poly(Glu:Tyr) 4:1 as substrate.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Supplied as sterile solution of 20 mM Tris, 500 mM NaCl, pH 8.0, 3 mM DTT, 10 % glycerol

Konservierungsmittel: Dithiothreitol (DTT)

Vorsichtsmaßnahmen: This product contains Dithiothreitol (DTT): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Haltbarkeit: 6 months

Antigendetails

Target: EPH Receptor B4 (EPHB4)

Andere Bezeichnung: EphB4/HTK

Hintergrund: HTK,MYK1,TYRO11,Ephrin type-B receptor 4 is a protein that in humans is encoded by the EPHB4 gene. It is a single-pass type I membrane protein belonging to the ephrin receptor subfamily of protein kinase superfamily. Members of the ephrin and Eph family are local mediators of cell function through largely contact-dependent processes in development and in maturity. Furthermore, EphB4 protein and the corresponding ligand Ephrin-B2 contribute to tumor growth in various human tumors. EphB4 protein has tumor suppressor activities and that regulation of cell proliferation, extracellular matrix remodeling, and invasive potential are important mechanisms of tumor suppression. Therefore, Ephrin-B2/EphB4 may be recognized as a novel prognostic indicator for cancers.

Molekulargewicht:

Calculated MW: 75.2 kDa

Observed MW: 66 kDa

Gen-ID: 2050

UniProt: P54760

Pathways: RTK Signalweg