EPH Receptor B1 Protein (EPHB1) (AA 565-984)

Produktnummer ABIN7938802

Dieses Recombinant EPH Receptor B1-Protein wird in Baculovirus infected Insect Cells exprimiert.

Kurzübersicht für EPH Receptor B1 Protein (EPHB1) (AA 565-984) (ABIN7938802)

Target: EPH Receptor B1 (EPHB1)

Protein-Typ: Recombinant

Spezies: Human

Quelle: Baculovirus infected Insect Cells

Applikation: Activity Assay (AcA), Functional Studies (Func), Screening Assay (ScA)

Produktdetails

Proteineigenschaft: AA 565-984

Verwendungszweck: Recombinant EPHB1 (565-984) protein

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Recombinant EPHB1 (565-984) protein is supplied in 25 mM HEPESNaOH pH 7.5, 300 mM NaCl, 10 % glycerol, 0.04 % Triton X-100 and 0.5 mM TCEP.

Handhabung: Avoid repeated freeze/thaw cycles,keep on ice when not in storage

Lagerung: -80 °C

Informationen zur Lagerung: Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Antigendetails

Target: EPH Receptor B1 (EPHB1)

Andere Bezeichnung: EPHB1

Hintergrund:

Protein Background: EPHB1(Ephrin type-B receptor 1) is a receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Cognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3. During nervous system development, regulates retinal axon guidance redirecting ipsilaterally ventrotemporal retinal ganglion cells axons at the optic chiasm midline. This probably requires repulsive interaction with EFNB2. In the adult nervous system together with EFNB3, regulates chemotaxis, proliferation and polarity of the hippocampus neural progenitors. In addition to its role in axon guidance also plays an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and synapse formation. May also regulate angiogenesis. More generally, may play a role in targeted cell migration and adhesion. Upon activation by EFNB1 and probably other ephrin-B ligands activates the MAPK/ERK and the JNK signaling cascades to regulate cell migration and adhesion respectively. Involved in the maintenance of the pool of satellite cells (muscle stem cells) by promoting their selfrenewal and reducing their activation and differentiation (By similarity).

Short Description: Recombinant EPHB1 (565-984) protein that includes amino acids 565-984 of human EPHB1 protein (accession number NP_004432.1) was expressed in a baculovirus expression system, and contains an N-terminal FLAG tag. The molecular weight of the protein is 48.78 kDa.

Aliases: Ephrin type-B receptor 1, EPHT2, HEK6, ELK, NET, EK6, Eph Tyrosine Kinase

Pathways: RTK Signalweg