M-CSF/CSF1 Protein

Produktnummer ABIN7866449

Recombinant M-CSF/CSF1-Protein exprimiert in Escherichia coli (E. coli).

Kurzübersicht für M-CSF/CSF1 Protein (ABIN7866449)

Target: M-CSF/CSF1 (CSF1) (Colony Stimulating Factor 1 (Macrophage) (CSF1))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Spezies: Maus

Quelle: Escherichia coli (E. coli)

Reinheit: > 98 % by SDS-PAGE

Produktdetails

Verwendungszweck: Recombinant Mouse M-CSF Protein

Sequenz: MKEVSEHCSH MIGNGHLKVL QQLIDSQMET SCQIAFEFVD QEQLDDPVCY LKKAFFLVQD IIDETMRFKD NTPNANATER LQELSNNLNS CFTKDYEEQN KACVRTFHET PLQLLEKIKN FFNETKNLLE KDWNIFTKNC NNSFAKCSSR DVVTKP

Spezifität: Chromosomal location:3 F3, 3 51.0 cM

Produktmerkmale: Length (aa):156

Anwendungsinformationen

Applikationshinweise: The biological activity was determined by the induction of proliferation in the NFS 60 cell line.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: water,Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-0.5 mg/mL. Do not vortex. This solution can be stored at 2-8 °C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1 % BSA) and store in working aliquots at -20 °C to -80 °C.

Buffer: PBS

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: The lyophilized protein is stable at room temperature for 1 month and at 4°C for 6 months. Reconstituted working aliquots are stable for 1 week at 2°C to 8°C and for 12 months at -20°C to -80°C.

Haltbarkeit: 12 months

Antigendetails

Target: M-CSF/CSF1 (CSF1) (Colony Stimulating Factor 1 (Macrophage) (CSF1))

Andere Bezeichnung: M-CSF

Hintergrund:

Synonyms: Csf1, op, Csfm, MCSF, C87615

Description: M-CSF is a potent hematopoietic factor produced by a variety of cells including lymphocytes, monocytes, fibroblasts, endothelial cells, myoblasts and osteoblasts. It is a key regulator of cellular proliferation, differentiation, and survival of blood monocytes, tissue macrophages and their progenitor cells. M-CSF has been shown to play important roles in modulating dermal thickness, and male and female fertility. M-CSF is clinically used in the treatment of infection, malignancies and atherosclerosis. It facilitates hematopoietic recovery after bone marrow transplantation. The human is reactive in murine systems, but the murine molecule exhibits no activity on human cells. Recombinant murine M-CSF is a 36.4 kDa homodimeric protein containing two 156 amino acid polypeptide subunits.

Molekulargewicht: 36.4 kDa

Gen-ID: 12977

NCBI Accession: NM_007778, NP_031804

UniProt: P07141

Pathways: RTK Signalweg