IL-13 Protein

Produktnummer ABIN7849723

Dieses Recombinant IL-13-Protein wird in Human Cells produziert.

Kurzübersicht für IL-13 Protein (ABIN7849723)

Target: IL-13 (IL13) (Interleukin 13 (IL13))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Human Cells

Applikation: SDS-PAGE (SDS)

Reinheit: >95 % by SDS-PAGE

Produktdetails

Verwendungszweck: Recombinant Human IL-13 Protein

Sterilität: 0.2 μm filtered

Endotoxin-Niveau: <0.01 EU/μg by LAL test

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Dissolve the lyophilized protein in distilled water(It is not recommended to reconstitute to a concentration<100 μg/mL.)

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Ship at 4°C.Upon receipt, aliquot and store at -20°C or -80°C for long term. Avoid repeated freeze and thaw cycles.

Antigendetails

Target: IL-13 (IL13) (Interleukin 13 (IL13))

Andere Bezeichnung: IL-13

Hintergrund:

Synonyms: IL13, IL-13, P600, interleukin 13

Description: Recombinant human IL-13 is produced by the mammalian system, with the target gene encoding Gly35-Asn146 expressed with 6x His-tag at the C-terminus.

Background: Interleukin 13 (IL-13) is a protein that in humans is encoded by the IL13 gene.IL-13 was first cloned in 1993 and is located on chromosome 5q31.1 with a length of 1.4kb.It has a mass of 13 kDa and folds into 4 alpha helical bundles.The secondary structural features of IL-13 are similar to that of Interleukin 4 (IL-4), however it only has 25 % sequence identity to IL-4 and is capable of IL-4 independent signaling.IL-13 is a cytokine secreted by T helper type 2 (Th2) cells, CD4 cells, natural killer T cell, mast cells, basophils, eosinophils and nuocytes.Interleukin-13 is a central regulator in IgE synthesis, goblet cell hyperplasia, mucus hypersecretion, airway hyperresponsiveness, fibrosis and chitinase up-regulation.It is a mediator of allergic inflammation and different diseases including asthma,and atopic dermatitis.

Pathways: JAK-STAT Signalweg, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Proton Transport