IGFBP4 Protein
Kurzübersicht für IGFBP4 Protein (ABIN7849677)
Target
Alle IGFBP4 Proteine anzeigenProtein-Typ
Spezies
Quelle
Applikation
Reinheit
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Verwendungszweck
- Recombinant Human IGFBP4 Protein
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Insulin-Like Growth Factor Binding Protein 4 (IGFBP4) (AA 1-258) protein (GST tag)
IGFBP4 Spezies: Human Wirt: Wheat germ Recombinant WB, ELISA, AP, AA
Insulin-Like Growth Factor Binding Protein 4 (IGFBP4) (AA 1-258) (Active) protein (His tag)IGFBP4 Spezies: Human Wirt: Mammalian Cells Recombinant >90 % as determined by SDS-PAGE. WB, SDS, Imm, ELISA, AcA Active
Insulin-Like Growth Factor Binding Protein 4 (IGFBP4) (AA 22-258) protein (His-IF2DI Tag)IGFBP4 Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
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Applikationshinweise
- Optimal working dilution should be determined by the investigator.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Buffer
- 20 mM Tris-HCl, 300 mM NaCl, pH 9.0 with 0.2 % SKL as the preservative.
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Lagerung
- 4 °C,-20 °C
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Informationen zur Lagerung
- Ship at 4°C. Upon receipt, aliquot and store at -20°C for long term. Avoid repeated freeze and thaw cycles.
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- IGFBP4 (Insulin-Like Growth Factor Binding Protein 4 (IGFBP4))
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Andere Bezeichnung
- IGFBP4
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Hintergrund
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Synonyms: Insulin-like growth factor-binding protein 4, IGFBP4, IBP-4, IGF-binding protein 4, IGFBP-4, IBP4
Description: Recombinant human Insulin Like Growth Factor Binding 4 protein with molecular weight of 31.7 kDa.
Background: Insulin-like growth factor-binding protein 4 is a protein that in humans is encoded by the IGFBP4 gene.IGFBP4 maternal blood concentrations were lower during pregnancy than during non-pregnant cycles and synchronized control cycles. It can be speculated that the lower IGFBP4 in maternal blood may result in an increase of free IGF1 for local action. IGFBP4 downregulation in GCTs compared to MSCs. Overexpression of UCHL1 and IGFBP4 by stable transfection of GCTSC did not influence cell viability, proliferation, migration and chemosensitivity compared to parental cells. However, colony-formation was significantly decreased suggesting that rescue of UCHL1 and IFGBP4 suppresses clonogenicity of GCT stromal cells. Epigenetic silencing of UCHL1 and IGFBP4 in GCTs might thus be a crucial event during the malignant transformation of MSCs in the context of GCT development and represent promising targets for the development of new diagnostic and therapeutic strategies.
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Pathways
- WNT Signalweg, Myometrial Relaxation and Contraction, Regulation of Carbohydrate Metabolic Process
Target
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