CSK Protein (His-GST)

Produktnummer ABIN7668267

Recombinant CSK-Protein exprimiert in Baculovirus infected Insect Cells.

Kurzübersicht für CSK Protein (His-GST) (ABIN7668267)

Target: CSK (C-Src tyrosine Kinase (CSK))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Spezies: Maus

Quelle: Baculovirus infected Insect Cells

Reinheit: > 90 %

Produktdetails

Aufreinigungstag / Konjugat: Dieses CSK Protein ist gelabelt mit His-GST.

Verwendungszweck: Recombinant Mouse SRC Kinase/c-SRC Protein (His & GST Tag)

Sequenz: Met 1-Leu 535

Aufreinigung: > 95 % as determined by reducing SDS-PAGE.

Sterilität: 0.2 μm filtered

Endotoxin-Niveau: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: The specific activity was determined to be > 80 nmol/min/mg using poly [Glu, Tyr] 4:1 as substrate.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Supplied as sterile solution of 20 mM Tris, 500 mM NaCl, 10 % glycerol, pH 8.0

Lagerung: -20 °C

Informationen zur Lagerung: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Antigendetails

Target: CSK (C-Src tyrosine Kinase (CSK))

Andere Bezeichnung: SRC Kinase

Hintergrund: Proto-oncogene tyrosine-protein kinase SRC is a hydrophobic protein belonging to the SRC family kinase including nine members that is a family of non-receptor tyrosine kinases. SRC protein may exist in different forms: C-SRC and V-SRC. C-SRC is only activated under certain circumstances where it is required such as growth factor signaling, while V-SRC is a constitutively active as opposed to normal SRC (C-SRC). Thus, V-SRC is an instructive example of an oncogene protein kinase whereas C-SRC is a proto-oncogene protein kinase. Inhibition of SRC with NR2A tyrosine phosphorylation mediated by PSD-95 may contribute to the lithium-induced downregulation of NMDA receptor function and provide neuroprotection against excitotoxicity.,AW259666,pp60c-src

Molekulargewicht:

calculated_mw: 87.7 kDa

observed_mw: 80 kDa

Pathways: T-Zell Rezeptor Signalweg, EGFR Signaling Pathway, Cell-Cell Junction Organization, CXCR4-mediated Signaling Events