IL-15 Protein (AA 49-162) (His tag)

Produktnummer ABIN7566189

Produktdetails

Target: IL-15 (IL15) (Interleukin 15 (IL15))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Proteineigenschaft: AA 49-162

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses IL-15 Protein ist gelabelt mit His tag.

Verwendungszweck: IL-15 (human) (rec.) (His)

Kreuzreaktivität: Human

Produktmerkmale: The extracellular domain of human IL-15 (aa 49-162) is fused at the C-terminus to a His-tag.

Reinheit: >95 % (SDS-PAGE)

Sterilität: Sterile filtered

Endotoxin-Niveau: <0.1EU/μg protein (LAL test, Lonza).

Biological Activity Comment: Measured by its ability to stimulate the proliferation of mouse CTLL-2 cells. The ED50 for this effect is typically 0.5ng/mL, corresponding to a specific activity of 2x 106 units/mg

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Lyophilized from 0.2μm-filtered solution in PBS.

Handhabung: Avoid freeze/thaw cycles.Centrifuge lyophilized vial before opening and reconstitution.PBS containing at least 0.1 % BSA should be used for further dilutions.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung:

Short Term Storage: +4°C

Long Term Storage: -20°C

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.

Antigendetails

Target: IL-15 (IL15) (Interleukin 15 (IL15))

Andere Bezeichnung: IL-15 (IL15 Produkte)

Hintergrund:

Interleukin-15

Interleukin-15 (IL-15) has a broad spectrum of biological activities. It is crucial for the development, proliferation, survival and differentiation of multiple cells from both innate and adaptive immune systems. IL-15 up-regulation has a central role in the development of several autoimmune or chronic inflammatory disorders. Targeting IL-15 or its receptor may have a valuable impact on the treatment of immune-mediated diseases. IL-15 participates in the development of important immune antitumor mechanisms. It activates CD8(+) T cells, natural killer (NK) cells, NK T cells, and can promote the formation of antitumor antibodies. IL-15 can also protect T effector cells from the action of T regulatory cells and reverse tolerance to tumor-associated antigens. In pre-clinical studies IL-15 has been found to demonstrate potentiated antitumor effects following pre-association with IL-15Ralpha, or when used in combination with chemotherapy, adoptive therapy, monoclonal antibodies, and tumor vaccines.

Molekulargewicht: ~14kDa (SDS-PAGE)

NCBI Accession: NP_751914

Pathways: JAK-STAT Signalweg, Glycosaminoglycan Metabolic Process