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Flagellin Protein (FliC) (AA 1-495, active-Mutant)

FliC Spezies: Salmonella typhimurium Wirt: Escherichia coli (E. coli) Recombinant >95 % (SDS-PAGE) Active
Produktnummer ABIN7566155
  • Target Alle Flagellin (FliC) Proteine anzeigen
    Flagellin (FliC)
    Protein-Typ
    Recombinant
    Biologische Aktivität
    Active
    Proteineigenschaft
    AA 1-495, active-Mutant
    Spezies
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Salmonella typhimurium
    Quelle
    • 7
    • 5
    • 2
    Escherichia coli (E. coli)
    Verwendungszweck
    Flagellin (rec.) (untagged) (highly active)
    Kreuzreaktivität
    Human, Maus
    Produktmerkmale
    Native flagellin [FliC] from Salmonella enterica Serovar Typhimurium strain ATCC14028 (aa 1-495).
    Reinheit
    >95 % (SDS-PAGE)
    Endotoxin-Niveau
    <0.001EU/μg purified protein (LAL test, Lonza).
    Biological Activity Comment
    Activation of TLR5 in human epithelial cell assays based on NF-kappaB luciferase fusions, on expression of IL-8 (CXCL8), CCL20, inducible nitric oxide synthase, beta-defensin 2 and matrilysin (MMP-7). Maturation of dendritic cells in in vitro and in vivo assays. Adjuvant activity on foreign antigens delivered by subcutaneous and intranasal routes in mice. TLR5 can be stimulated in vitro by Flagellin (rec.) (untagged) (highly active) at a concentration of 5-50ng/ml and in vivo at a starting concentration of 0.1-1μg/mouse.
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  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    1 mg/mL after reconstitution.
    Konzentration
    1 mg/mL
    Buffer
    Contains PBS.
    Handhabung
    After reconstitution, prepare aliquots and store at -20 °C. Avoid freeze/thaw cycles. Centrifuge lyophilized vial before opening and reconstitution.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung

    Short Term Storage: +4°C

    Long Term Storage: -20°C

    Use & Stability: Stable for at least 6 months after receipt when stored at -20°C.

  • Target
    Flagellin (FliC)
    Andere Bezeichnung
    Flagellin (FliC Produkte)
    Hintergrund

    FliC

    Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. It activates the innate immune system through the receptor Toll-like Receptor 5 (TLR5) and the intracellular protein NLRC4 (NLR family CARD domain-containing protein 4).

    Molekulargewicht
    ~54kDa (SDS-PAGE)
    UniProt
    P06179
    Pathways
    Inflammasome
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