ROR2 Protein (Soluble)

Produktnummer ABIN7539348

Recombinant ROR2-Protein exprimiert in Insektenzellen.

Kurzübersicht für ROR2 Protein (Soluble) (ABIN7539348)

Target: ROR2 (Receptor Tyrosine Kinase-Like Orphan Receptor 2 (ROR2))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Spezies: Human

Quelle: Insektenzellen

Reinheit: > 98 % by SDS-PAGE and Coomassie stain

Produktdetails

Proteineigenschaft: Soluble

Verwendungszweck: ROR2, soluble

Sequenz: EVEVLDPNDP LGPLDGQDGP IPTLKGYFLN FLEPVNNITI VQGQTAILHC KVAGNPPPNV RWLKNDAPVV QEPRRIIIRK TEYGSRLRIQ DLDTTDTGYY QCVATNGMKT ITATGVLFVR LGPTHSPNHN FQDDYHEDGF CQPYRGIACA RFIGNRTIYV DSLQMQGEIE NRITAAFTMI GTSTHLSDQC SQFAIPSFCH FVFPLCDARS RTPKPRELCR DECEVLESDL CRQEYTIARS NPLILMRLQL PKCEALPMPE SPDAANCMRI GIPAERLGRY HQCYNGSGMD YRGTASTTKS GHQCQPWALQ HPHSHHLSST DFPELGGGHA YCRNPGGQME GPWCFTQNKN VRMELCDVPS CSPRDSSKMG HHHHHH

Produktmerkmale: Length (aa):376

Anwendungsinformationen

Applikationshinweise: Binds rh Wnt5a in a functional ELISA.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Centrifuge vial prior to opening. The lyophilized sROR2 is soluble in water and most aqueous buffers and should be reconstituted in water to a concentration not lower than 100 μg/mL.

Buffer: PBS

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Lyophilized samples are stable for greater than six months at -20°C to -70°C. Reconstituted sROR2 should be stored in working aliquots at -70°C.

Haltbarkeit: 6 months

Antigendetails

Target: ROR2 (Receptor Tyrosine Kinase-Like Orphan Receptor 2 (ROR2))

Andere Bezeichnung: ROR2

Hintergrund: Neurotrophic tyrosine kinase, receptor-related 2,ROR2 is a signaling receptor for Wnt ligands that is known to play important roles in limb development, but having no essential roles known in adult tissues. Recent evidence has implicated ROR2 in mediating both canonical and non-canonical signaling pathways. ROR2 was initially found to be highly expressed in osteosarcoma and renal cell carcinomas, and has recently been found in an increasingly long list of cancers currently including melanoma, colon cancer, melanoma, squamous cell carcinoma of the head and neck, and breast cancer. In the majority of these cancer types, ROR2 expression is associated with more aggressive disease states, consistent with a role mediating Wnt signaling regardless of the canonical or non-canonical signal. Because of the pattern of tissue distribution, the association with high-risk diseases, and the cell surface localization of this receptor, ROR2 has been identified as a potential high value target for therapeutic development. However, the recent discovery that ROR2 may function through non-kinase activities challenges this strategy and opens up opportunities to target this important molecule through alternative means.

Molekulargewicht: 50.0 kDa

Gen-ID: 4920

NCBI Accession: NM_004560, NP_004551

UniProt: Q01974

Pathways: RTK Signalweg, WNT Signalweg