MME Protein (AA 52-750)

Produktnummer ABIN7504255

Dieses Recombinant MME-Protein wird in HEK-293 Cells exprimiert.

Kurzübersicht für MME Protein (AA 52-750) (ABIN7504255)

Target: MME (Membrane Metallo-Endopeptidase (MME))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Spezies: Human

Quelle: HEK-293 Cells

Reinheit: > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC

Produktdetails

Proteineigenschaft: AA 52-750

Verwendungszweck: Human CD10/MME Protein

Sequenz: Tyr52-Trp750

Produktmerkmale: Recombinant Human CD10/MME Protein is expressed from HEK293 without tag.It contains Tyr52-Trp750.

Sterilität: 0.22 μm filtered

Endotoxin-Niveau: Less than 1 EU per μg by the LAL method.

Biological Activity Comment: Human CD10 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.,Measured by its ability to cleave the fluorogenic peptide substrate, Mca-RPPGFSAFK (Dnp) -OH. The specific activity is > 1500 pmoles/min/ug.,The purity of Human CD10 is greater than 95% as determined by SEC-HPLC.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Supplied as 0.22 μm filtered solution in 50 mM MES, 100 mM NaCl, 10 % glycerol ( pH 6.5).

Lagerung: -80 °C

Informationen zur Lagerung: Valid for 12 months from date of receipt when stored at -80°C., Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Haltbarkeit: 12 months

Antigendetails

Target: MME (Membrane Metallo-Endopeptidase (MME))

Andere Bezeichnung: CD10

Hintergrund: CD10 is an endopeptidase that degrades various bioactive peptides in the extracellular matrix. In addition to enzymatic degradation, it affects multiple intracellular signal transduction pathways. CD10 expression has been extensively studied in human epithelial cancers of numerous organs and sites. CD10 expression pattern depended on the histotypes of thyroid lesions. When possible metastatic tumours and non-epithelial tumours are excluded, high CD10 expression may be useful in determining whether a primary thyroid carcinoma includes an anaplastic component.

Molekulargewicht: 79.83 kDa. Due to glycosylation, the protein migrates to 80-100 kDa based on Bis-Tris PAGE result.

UniProt: P08473

Pathways: RTK Signalweg, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Smooth Muscle Cell Migration