IL-15 Protein

Produktnummer ABIN7488868

Dieses Recombinant IL-15-Protein wird in HEK-293 Cells exprimiert.

Kurzübersicht für IL-15 Protein (ABIN7488868)

Target: IL-15 (IL15) (Interleukin 15 (IL15))

Protein-Typ: Recombinant

Spezies: Human

Quelle: HEK-293 Cells

Reinheit: 95 %

Güteklasse: Premium grade

Produktdetails

Verwendungszweck: Human IL-15 Protein, premium grade

Sequenz: Asn 49 - Ser 162

Produktmerkmale: Human IL-15, premium grade is expressed from human 293 cells (HEK293). It contains AA Asn 49 - Ser 162 (Accession # P40933-1).

Endotoxin-Niveau: 0.01 EU per μg

Anwendungsinformationen

Kommentare:

This protein carries no "tag". () The protein has a calculated MW of 12.8 kDa. As a result of glycosylation, the protein migrates as 14-16 kDa under reducing (R) condition, and 14 kDa under non-reducing (NR) condition (SDS-PAGE).

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: PBS, pH 7.4

Lagerung: -20 °C

Informationen zur Lagerung: -20°C

Antigendetails

Target: IL-15 (IL15) (Interleukin 15 (IL15))

Andere Bezeichnung: IL-15

Hintergrund: Interleukin 15 is also known as IL15, IL-15, and is a cytokine with structural similarity to IL-2. Like IL-2, IL-15 binds to and signals through the IL-2/IL-15 beta chain (CD122) and the common gamma chain (gamma-C, CD132). IL-15 is secreted by mononuclear phagocytes (and some other cells) following infection by virus(es). This cytokine induces cell proliferation of natural killer cells, cells of the innate immune system whose principal role is to kill virally infected cells. Interleukin 15 (IL-15) regulates T and natural killer (NK) cell activation and proliferation. Survival signals that maintain memory T cells in the absence of antigen are provided by IL-15. This cytokine is also implicated in NK cell development. In rodent lymphocytes, IL-15 prevents apoptosis by inducing an apoptosis inhibitor, BCL2L1/BCL-x(L). IL-15 has been shown to enhance the anti-tumor immunity of CD8+ T cells in pre-clinical models. A phase I clinical trial to evaluate the safety, dosing, and anti-tumor efficacy of IL-15 in patients with metastatic melanoma and renal cell carcinoma (kidney cancer) has begun to enroll patients at the National Institutes of Health.

Molekulargewicht: 12.8 kDa

Pathways: JAK-STAT Signalweg, Glycosaminoglycan Metabolic Process