CD40 Ligand Protein (CD40LG) (Fc Tag)

Produktnummer ABIN7491135

Dieses Recombinant CD40 Ligand-Protein wird in HEK-293 Cells exprimiert.

Kurzübersicht für CD40 Ligand Protein (CD40LG) (Fc Tag) (ABIN7491135)

Target: CD40 Ligand (CD40LG)

Protein-Typ: Recombinant

Spezies: Maus

Quelle: HEK-293 Cells

Reinheit: The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.

Produktdetails

Aufreinigungstag / Konjugat: Dieses CD40 Ligand Protein ist gelabelt mit Fc Tag.

Verwendungszweck: Recombinant mouse CD40L protein with N-terminal human Fc tag

Spezifität: HFc (Glu99-Ala330) Mouse CD40 Ligand (Gly115-Leu260)

Produktmerkmale: Extracellular Domain Protein

Aufreinigung: Purified from cell culture supernatant by affinity chromatography

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Haltbarkeit: 12 months

Antigendetails

Target: CD40 Ligand (CD40LG)

Andere Bezeichnung: CD40 Ligand

Hintergrund: Cytokine that binds to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation. Induces the activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4. Involved in immunoglobulin class switching (PubMed:1374165).[UniProtKB/Swiss-Prot Function]

Molekulargewicht: predicted molecular mass of 42.1 kDa after removal of the signal peptide. The apparent molecular mass of hFc-CD40L is 40-55 kDa due to glycosylation.

UniProt: P27548

Pathways: NF-kappaB Signalweg, Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints