KIT Ligand Protein (KITLG) (AA 26-189)

Produktnummer ABIN7447897

Dieses Recombinant KIT Ligand-Protein wird in HEK-293 Cells produziert.

Kurzübersicht für KIT Ligand Protein (KITLG) (AA 26-189) (ABIN7447897)

Target: KIT Ligand (KITLG)

Protein-Typ: Recombinant

Spezies: Human

Quelle: HEK-293 Cells

Reinheit: 90,00 %

Produktdetails

Proteineigenschaft: AA 26-189

Verwendungszweck: Human SCF / KITLG (26-189) Protein, premium grade

Marke: Premium grade

Sequenz: Glu 26 - Ala 189

Produktmerkmale: Human SCF (26-189), premium grade is expressed from human 293 cells (HEK293). It contains AA Glu 26 - Ala 189 (Accession # P21583-1).
Premium grade: This product is produced under rigorous quality control system that incorporates a comprehensive set of tests including sterility and endotoxin tests. Product performance is carefully validated and tested for compatibility for cell culture use or any other applications in the early preclinical stage.

Sterilität: Sterile

Endotoxin-Niveau: 0.1 EU per μg

Anwendungsinformationen

Kommentare:

This protein carries no "tag". The protein has a calculated MW of 18.5 kDa. The protein migrates as 20-33 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: PBS, pH 7.4

Lagerung: -20 °C

Informationen zur Lagerung: -20°C

Antigendetails

Target: KIT Ligand (KITLG)

Andere Bezeichnung: SCF

Hintergrund: Synonyms:KITLG,FPH2,KL-1,Kitl,MGF,SCF,SF,SHEP7,KL,Description:Stem Cell Factor is also known as SCF, kit-ligand, KL, steel factor, KITLG, FPH2, KL-1, Kitl, MGF, SCF, SF, or SHEP7, and is a cytokine that binds to the c-Kit receptor (CD117). SCF can exist both as a transmembrane protein and a soluble protein. This cytokine plays an important role in hematopoiesis (formation of blood cells), spermatogenesis, and melanogenesis. The soluble and transmembrane forms of the protein are formed by alternative splicing of the same R transcript.Soluble and transmembrane SCF is produced by fibroblasts and endothelial cells. Soluble SCF has a molecular weight of 18,5 KDa and forms a dimer. SCF plays an important role in the hematopoiesis during embryonic development. Sites where hematopoiesis takes place, such as the fetal liver and bone marrow, all express SCF. During development, the presence of the SCF also plays an important role in the localization of melanocytes, cells that produce melanin and control pigmentation. SCF plays a role in the regulation of HSCs in the stem cell niche in the bone marrow. SCF may be used along with other cytokines to culture HSCs and hematopoietic progenitors. The expansion of these cells ex-vivo (outside the body) would allow advances in bone-marrow transplantation, in which HSCs are transferred to a patient to re-establish blood formation.

Molekulargewicht: 18.5 kDa

Pathways: RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung