KIT Ligand Protein (KITLG) (AA 26-189) (His tag)

Produktnummer ABIN7321261

Recombinant KIT Ligand-Protein exprimiert in Escherichia coli (E. coli).

Kurzübersicht für KIT Ligand Protein (KITLG) (AA 26-189) (His tag) (ABIN7321261)

Target: KIT Ligand (KITLG)

Protein-Typ: Recombinant

Spezies: Ratte

Quelle: Escherichia coli (E. coli)

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Produktdetails

Proteineigenschaft: AA 26-189

Aufreinigungstag / Konjugat: Dieses KIT Ligand Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Rat SCF/c-Kit Ligand Protein (E.coli, His Tag)

Sequenz: Gln26-Ala189

Produktmerkmale: Recombinant Rat Stem Cell Factor is produced by our E.coli expression system and the target gene encoding Gln26-Ala189 is expressed with a 6His tag at the C-terminus.

Sterilität: 0.2 μm filtered

Endotoxin-Niveau: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: Not validated for activity

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Haltbarkeit: 12 months

Antigendetails

Target: KIT Ligand (KITLG)

Andere Bezeichnung: SCF/c-Kit Ligand

Hintergrund: FPH2,KIT ligand,KITLG,KL-1,Kitl,MGF,MGFSHEP7,Mast cell growth factor,SCF,SFc-Kit ligand,SLF,Stem Cell Factor,c-kit Ligand,steel factor,Stem cell factor (SCF), is the ligand for the receptor-type protein-tyrosine kinase KIT. It plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. It also promotes phosphorylation of PIK3R1, which is the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5.

Molekulargewicht:

Calculated MW: 19.3 kDa

Observed MW: 18 kDa

Gen-ID: 60427

UniProt: P21581

Pathways: RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung