UNG Protein (GST tag)
Kurzübersicht für UNG Protein (GST tag) (ABIN7317329)
Target
Alle UNG Proteine anzeigenProtein-Typ
Spezies
Quelle
Reinheit
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Aufreinigungstag / Konjugat
- Dieses UNG Protein ist gelabelt mit GST tag.
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Verwendungszweck
- Recombinant Human Uracil-DNA glycosylase/UNG Protein (GST Tag)
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Sequenz
- Phe 85-Leu 304
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Produktmerkmale
- A DNA sequence encoding the human UNG isoform 1 (P13051-2) (Phe 85-Leu 304) was fused with the GST tag at the N-terminus.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Lyophilized
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Rekonstitution
- Please refer to the printed manual for detailed information.
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Buffer
- Lyophilized from sterile 40 mM Tris, 0.15M NaCl, 2 mM GSH, pH 7.5
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Lagerung
- 4 °C,-20 °C,-80 °C
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Informationen zur Lagerung
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- UNG (Uracil-DNA Glycosylase (UNG))
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Andere Bezeichnung
- Uracil-DNA glycosylase/UNG
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Substanzklasse
- Viral Protein
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Hintergrund
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Background: Isoform 1 is widely expressed with the highest expression in skeletal muscle, heart and testicles. Isoform 2 has the highest expression levels in tissues containing proliferating cells. Uracil-DNA glycosylase exists in two forms: mitochondrial uracil-DNA glycosylase 1 (UNG1) and nuclear uracil-DNA glycosylase 2 (UNG2). uracil-DNA glycosylase. This gene encodes one of several uracil-DNA glycosylases. One important function of uracil-DNA glycosylases is to prevent mutagenesis by eliminating uracil from DNA molecules by cleaving the N-glycosylic bond and initiating the base-excision repair (BER) pathway. Uracil bases occur from cytosine deamination or misincorporation of dUMP residues. Alternative promoter usage and splicing of this gene leads to two different isoforms: the mitochondrial UNG1 and the nuclear UNG2. The UNG2 term was used as a previous symbol for the CCNO gene (GeneID 10309), which has been confused with this gene, in the literature and some databases. Defects in UNG are a cause of immunodeficiency with hyper-IgM type 5 (HIGM5). A rare immunodeficiency syndrome characterized by normal or elevated serum IgM levels with absence of IgG, IgA, and IgE. It results in a profound susceptibility to bacterial infections.
Synonym: DGU,HIGM4,HIGM5,UDG,UNG1,UNG15,UNG2
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Molekulargewicht
- 52 kDa
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Pathways
- DNA Reparatur, Production of Molecular Mediator of Immune Response
Target
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