TNFSF14 Protein (mFc Tag)

Produktnummer ABIN7319434

Dieses Recombinant TNFSF14-Protein wird in Human Cells exprimiert.

Kurzübersicht für TNFSF14 Protein (mFc Tag) (ABIN7319434)

Target: TNFSF14 (Tumor Necrosis Factor (Ligand) Superfamily, Member 14 (TNFSF14))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Human Cells

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Produktdetails

Aufreinigungstag / Konjugat: Dieses TNFSF14 Protein ist gelabelt mit mFc Tag.

Verwendungszweck: Recombinant Human TNFSF14/LIGHT Protein (mFc Tag)

Sequenz: Ile84-Val240(Lys214Glu)

Produktmerkmale: Recombinant Human LIGHT is produced by our Mammalian expression system and the target gene encoding Ile84-Val240(Lys214Glu) is expressed with a mFc tag at the N-terminus.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: TNFSF14 (Tumor Necrosis Factor (Ligand) Superfamily, Member 14 (TNFSF14))

Andere Bezeichnung: TNFSF14/LIGHT

Hintergrund:

Background: Human TNFSF14 Protein, also known as LIGHT, belongs to a member of the tumor necrosis factor (TNF) ligand family. It can bind to NFRSF3/LTBR. It is a ligand for TNFRSF14, which is a member of the tumor necrosis factor receptor superfamily, and it is also known as a herpesvirus entry mediator ligand (HVEML). TNFSF14 encodes a protein with a 37 aa cytoplasmic domain, 21aa transmembrane domain and 182 aa extracellular region. The gene is predominantly expressed in the spleen and also found in the brain. Weakly expressed in peripheral lymphoid tissues and in heart, placenta, liver, lung, appendix, and kidney, and no expression seen in fetal tissues, endocrine glands, or nonhematopoietic tumor lines. TNFSF14 protein was found to probably function as a costimulatory factor for the activation of lymphoid cells and as a deterrent to infection by herpesvirus. Studies have shown that this protein can prevent tumor necrosis factor alpha mediated apoptosis in primary hepatocyte. Two alternatively spliced transcript variant encoding distinct isoforms have been reported.

Synonym: CD258,HVEML,LIGHT,LTg,TR2,Tumor necrosis factor ligand superfamily member 14, Herpes virus entry mediator ligand, TNFSF14, HVEM-L, LIGHT

Molekulargewicht: 43.3 kDa

UniProt: O43557

Pathways: Cancer Immune Checkpoints