Thrombomodulin Protein (THBD) (His tag)

Produktnummer ABIN7319438

Dieses Recombinant Thrombomodulin-Protein wird in Human Cells produziert.

Kurzübersicht für Thrombomodulin Protein (THBD) (His tag) (ABIN7319438)

Target: Thrombomodulin (THBD)

Protein-Typ: Recombinant

Spezies: Human

Quelle: Human Cells

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Produktdetails

Aufreinigungstag / Konjugat: Dieses Thrombomodulin Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human Thrombomodulin/CD141 Protein (His Tag)

Sequenz: Ala19-Ser515

Produktmerkmale: Recombinant Human Thrombomodulin is produced by our Mammalian expression system and the target gene encoding Ala19-Ser515 is expressed with a 6His tag at the C-terminus.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Frozen, Liquid

Buffer: Supplied as a 0.2 μm filtered solution of 20 mM Tris, 150 mM NaCl, pH 8.0.

Lagerung: -20 °C

Informationen zur Lagerung: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Antigendetails

Target: Thrombomodulin (THBD)

Andere Bezeichnung: Thrombomodulin/CD141

Hintergrund:

Background: Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Human Thrombomodulin/THBD predicts a signal peptide and a mature chain that consists of following domains: C-type lectin, EGF-like, transmembrane and cytoplasmic. Predominantly synthesized by vascular endothelial cells, THBD inhibits coagulation and fibrinolysis. THBD gene polymorphisims are associated with human disease and THBD plays a role in thrombosis, stroke, arteriosclerosis, and cancer. For example, increased serum levels of THBD, due to protease cleavage, have been associated with smoking, cardiac surgery, atherosclerosis, liver cirrhosis, diabetes mellitus, cerebral and myocardial infarction, and multiple sclerosis.

Synonym: Thrombomodulin, THBD, TM, Fetomodulin, CD141, THRM

Molekulargewicht: 52.9 kDa

UniProt: P07204