STAT1 Protein

Produktnummer ABIN7319272

Recombinant STAT1-Protein exprimiert in Escherichia coli (E. coli).

Kurzübersicht für STAT1 Protein (ABIN7319272)

Target: STAT1 (Signal Transducer and Activator of Transcription 1, 91kDa (STAT1))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Escherichia coli (E. coli)

Reinheit: > 68 % as determined by reducing SDS-PAGE.

Produktdetails

Verwendungszweck: Recombinant Human STAT1 Protein

Sequenz: Met 1-Val712

Produktmerkmale: Recombinant Human Signal Transducer and Activator of Transcription 1 is produced by our E.coli expression system and the target gene encoding Met1-Val712 is expressed.

Sterilität: 0.2 μm filtered

Endotoxin-Niveau: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: Not validated for activity

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 0.02 % Tween 80, 5 % Sucrose, 4 % Mannitol, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Haltbarkeit: 12 months

Antigendetails

Target: STAT1 (Signal Transducer and Activator of Transcription 1, 91kDa (STAT1))

Andere Bezeichnung: STAT1

Hintergrund: CANDF7,IMD31A,IMD31B,IMD31C,ISGF-3,STAT1,STAT91,Signal Transducer and Activator of Transcription 1-Alpha/Beta,Transcription Factor ISGF-3 Components p91/p84,Signal Transducer and Activator of Transcription 1-Alpha/Beta (STAT1) contains one SH2 domain and belongs to the transcription factor STAT family. When tyrosine- and serine-phosphorylated, STAT1 can form a homodimer termed IFN-gamma-activated factor (GAF), migrate into the nucleus and bind to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state. STAT1 functions as signal transducer and transcription activator that mediates cellular responses to interferons. Defects in STAT1 are the cause of STAT1 deficiency complete and familial candidiasis type 7.

Molekulargewicht:

Calculated MW: 83.3 kDa

Observed MW: 85 kDa

Gen-ID: 6772

UniProt: P42224

Pathways: JAK-STAT Signalweg, RTK Signalweg, Interferon-gamma Pathway, Response to Growth Hormone Stimulus, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Endopeptidase Activity, Hepatitis C, CXCR4-mediated Signaling Events