Prolactin Protein (PRL) (His tag)

Produktnummer ABIN7321021

Dieses Recombinant Prolactin-Protein wird in Human Cells produziert.

Kurzübersicht für Prolactin Protein (PRL) (His tag) (ABIN7321021)

Target: Prolactin (PRL)

Protein-Typ: Recombinant

Spezies: Schaf

Quelle: Human Cells

Reinheit: >95 % as determined by reducing SDS-PAGE.

Produktdetails

Aufreinigungstag / Konjugat: Dieses Prolactin Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Sheep Prolactin/PRL (C-6His)

Sequenz: Thr31-Cys229

Produktmerkmale: Recombinant Sheep Prolactin is produced by our Mammalian expression system and the target gene encoding Thr31-Cys229 is expressed with a 6His tag at the C-terminus.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM Tris-HCl, 150 mM NaCl, pH 8.0.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: Prolactin (PRL)

Andere Bezeichnung: Prolactin/PRL

Hintergrund:

Background: Prolactin (PRL) is a secreted neuroendocrine pituitary hormone that acts primarily on the mammary gland to promote lactation, but has pleiotropic effects in both males and females. Non-glycosylated prolactin is produced by the pituitary and packaged in storage granules before secretion, while glycosylated prolactin is reported to be constitutively secreted, have lower biological potency, and be removed from the circulation more quickly. Prolactin is synthesized mainly by the anterior pituitary in all mammals, where secretion is under tonic inhibition by hypothalamic dopamine. In humans, prolactin is also produced peripherally. Prolactin expression is low during early human pregnancy, but increases in late pregnancy. The prolactin receptor (PRLR) is a transmembrane type I glycoprotein that belongs to the cytokine hematopoietic receptor family. prolactin molecule is thought to bind two receptor molecules. In addition to its lactogenic activity, peripherally produced prolactin plays roles in breast and prostate cancer development, regulation of reproductive function, and immunoregulation.

Synonym: Prolactin, PRL

Molekulargewicht: 23.5 kDa

UniProt: P01240

Pathways: JAK-STAT Signalweg, Peptide Hormone Metabolism, Response to Growth Hormone Stimulus, Protein targeting to Nucleus