MME Protein

Produktnummer ABIN7196973

Dieses Recombinant MME-Protein wird in HEK-293 Cells produziert.

Kurzübersicht für MME Protein (ABIN7196973)

Target: MME (Membrane Metallo-Endopeptidase (MME))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Spezies: Human

Quelle: HEK-293 Cells

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Produktdetails

Verwendungszweck: Recombinant Human CD10/Neprilysin Protein

Sequenz: Tyr 52-Trp 750

Produktmerkmale: A DNA sequence encoding the extracellular domain (Tyr 52-Trp 750) of human MME (NP_000893.2) was expressed and purified.

Sterilität: 0.2 μm filtered

Endotoxin-Niveau: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: Measured by its ability to cleave the fluorogenic peptide substrate, Mca-RPPGFSAFK(Dnp)-OH, (R&D Systems, Catalog # ES005). The specific activity is > 1, 000 pmoles/min/μg.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Haltbarkeit: 12 months

Antigendetails

Target: MME (Membrane Metallo-Endopeptidase (MME))

Andere Bezeichnung: CD10/Neprilysin

Hintergrund: SCA,Neutral endopeptidase 24.,CALLA,CD10,CMT2T,NEP,SCA43,SFE,MME,Atriopeptidase,Common acute lymphocytic leukemia antigen,Enkephalinase,Neprilysin,Neutral endopeptidase,Neutral endopeptidase 24.11,Skin fibroblast elastase,EPN, NEP, gp100,CD10 antigen,CD10),DKFZp686O16152,EC 3.4.24.11,enkephalinase),Membrane metallo endopeptidase,Membrane metallo endopeptidase (neutral endopeptidase,Membrane metallo endopeptidase variant 1,Membrane metallo endopeptidase variant 2,Membrane metalloendopeptidase,Membrane metalloendopeptidase neutral endopeptidase enkephalinase,Membrane metalloendopeptidase neutral endopeptidase enkephalinase CALLA CD10,Membrane metalloendopeptidase variant 1,Membrane metalloendopeptidase variant 2,membrane-associated,MGC126681,MGC126707,neprilysin-390,neprilysin-411,The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. Cluster of differentiation 10 (CD10), also known as Neprilysin and neutral endopeptidase, is a member of the CD system. CD10 is a zinc-dependent metalloprotease enzyme that had function to degrade a number of small secreted peptides such as the amyloid beta peptide. It exist as a membrane-bound protein and have high concentration in kidney and lung tissues. Mutations in the CD10 gene can induce the familial forms of Alzheimer's disease, providing strong evidence for the protein's association with the Alzheimer's disease process. CD10 is also associated with other biochemical processes.

Molekulargewicht:

Calculated MW: 80.0 kDa

Observed MW: 90-100 kDa

Gen-ID: 4311

NCBI Accession: NP_000893

UniProt: P08473

Pathways: RTK Signalweg, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Smooth Muscle Cell Migration