KIT Ligand Protein (KITLG) (His tag)

Produktnummer ABIN7321269

Dieses Recombinant KIT Ligand-Protein wird in Human Cells produziert.

Kurzübersicht für KIT Ligand Protein (KITLG) (His tag) (ABIN7321269)

Target: KIT Ligand (KITLG)

Protein-Typ: Recombinant

Spezies: Ratte

Quelle: Human Cells

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Produktdetails

Aufreinigungstag / Konjugat: Dieses KIT Ligand Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Rat SCF/c-Kit Ligand Protein (Human Cells, His Tag)

Sequenz: Gln26-Ala189

Produktmerkmale: Recombinant Rat SCF is produced by our Mammalian expression system and the target gene encoding Gln26-Ala189 is expressed with a 6His tag at the C-terminus.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: KIT Ligand (KITLG)

Andere Bezeichnung: SCF/c-Kit Ligand

Hintergrund:

Background: SCF/C-kit ligand is the ligand of the tyrosine-kinase receptor encoded by the KIT locus. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. In phase I/II clinical studies administration of the combination of SCF and G-CSF resulted in a two- to threefold increase in cells that express the CD34 antigen compared with G-CSF alone.

Synonym: FPH2, KIT ligand, Kitl, KITLG, KL-1, Mast cell growth factor, MGF, MGFSHEP7, SCF, SFc-Kit ligand, SLF, steel factor, Stem Cell Factor, c-kit Ligand

Molekulargewicht: 19.4 kDa

UniProt: P21581

Pathways: RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung