IL-7 Protein (His tag)

Produktnummer ABIN7320603

Dieses Recombinant IL-7-Protein wird in Human Cells exprimiert.

Kurzübersicht für IL-7 Protein (His tag) (ABIN7320603)

Target: IL-7 (IL7) (Interleukin 7 (IL7))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Spezies: Maus

Quelle: Human Cells

Reinheit: > 95 % as determined by SDS-PAGE

Produktdetails

Aufreinigungstag / Konjugat: Dieses IL-7 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Mouse Interleukin-7/IL-7 Protein (His Tag)(Active)

Sequenz: Glu26-Ile154

Produktmerkmale: Recombinant Mouse Interleukin-7 is produced by our Mammalian expression system and the target gene encoding Glu26-Ile154 is expressed with a 6His tag at the C-terminus.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Biological Activity Comment: Measured in a cell proliferation assay using PHA-activated human peripheral blood lymphocytes (PBL). The ED50 for this effect is 25-160 pg/ml.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: IL-7 (IL7) (Interleukin 7 (IL7))

Andere Bezeichnung: Interleukin-7/IL-7

Hintergrund:

Background: Mouse interleukin-7(IL-7) is the member of hemopoietin family which is important to the differentiation, proliferation, and survival of lymphocyte. Mouse IL-7 shares approximately 88 % aa sequence identity with rat IL-7 and 58-60 % with human, equine, bovine, ovine, porcine, feline and canine IL-7. It is widely expressed in primary and secondary lymphoid tissues cell and stromal epithelial cells of the thymus, bone marrow, and intestines. IL-7 activation of IL-7 R alpha is critical for both T cell and B cell lineage development. It is important for proliferation during certain stages of B-cell maturation. IL-7 contributes to the maintenance of all na?ve and memory T cells, mainly by promoting expression of the anti-apoptotic protein Bcl-2. It is required for optimal T cell-dendritic cell interaction.

Synonym: IL-7, IL-7 interleukin-7, interleukin-7, Lymphopoietin -1, PBGF

Molekulargewicht: 15.9 kDa

UniProt: P10168

Pathways: JAK-STAT Signalweg