Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

EPO Protein (His tag)

Recombinant EPO-Protein exprimiert in Human Cells.
Produktnummer ABIN7320904

Kurzübersicht für EPO Protein (His tag) (ABIN7320904)

Target

Alle EPO Proteine anzeigen
EPO (Erythropoietin (EPO))

Protein-Typ

Recombinant

Biologische Aktivität

Active

Spezies

  • 21
  • 8
  • 5
  • 4
  • 3
  • 3
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Maus

Quelle

  • 20
  • 15
  • 8
  • 7
  • 4
  • 2
  • 2
  • 1
  • 1
Human Cells

Reinheit

>95 % as determined by reducing SDS-PAGE.
  • Aufreinigungstag / Konjugat

    Dieses EPO Protein ist gelabelt mit His tag.

    Verwendungszweck

    Recombinant Mouse Erythropoietin/EPO (C-6His)

    Sequenz

    Ala27-Arg192

    Produktmerkmale

    Recombinant Mouse Erythropoietin is produced by our Mammalian expression system and the target gene encoding Ala27-Arg192 is expressed with a 6His tag at the C-terminus.

    Endotoxin-Niveau

    < 1.0 EU per μg as determined by the LAL method.

    Biological Activity Comment

    Measured in a cell proliferation assay using TF-1 human erythroleukemic cells. The ED50 for this effect is 0.35 ng/mL.
  • Möchten Sie weitere Optionen für dieses Protein ?

    !
    Entdecken Sie unsere vordefinierten maßgeschneiderten Proteine und Proteinservices!

    Ihr Projekt erfordert weitere Anpassungen? Kontaktieren Sie uns und entdecken Sie unsere maßgeschneiderten Proteinlösungen

  • Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Please refer to the printed manual for detailed information.

    Buffer

    Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

    Lagerung

    4 °C,-20 °C,-80 °C

    Informationen zur Lagerung

    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Target

    EPO (Erythropoietin (EPO))

    Andere Bezeichnung

    Erythropoietin/EPO

    Substanzklasse

    Hormone

    Hintergrund

    Background: Erythropoietin (EPO) is a glycoprotein hormone that is principally known for its role in erythropoiesis, where it is responsible for stimulating proliferation and differentiation of erythroid progenitor cells. Erythropoietin is a member of the EPO/TPO family. It is a secreted, glycosylated cytokine composed of four alpha helical bundles. The differentiation of CFU-E (Colony Forming Unit-Erythroid) cells into erythrocytes can only be accomplished in the presence of EPO. Physiological levels of EPO in adult mammals are maintained primarily by the kidneys, whereas levels in fetal or neonatal mammals are maintained by the liver. EPO also can exert various non-hematopoietic activities, including vascularization and proliferation of smooth muscle, neural protection during hypoxia, and stimulation of certain B cells. Genetic variation in erythropoietin is associated with susceptbility to microvascular complications of diabetes type 2. These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy.

    Synonym: Erythropoietin, Epoetin, EPO

    Molekulargewicht

    19.4 kDa

    UniProt

    Q0VED9

    Pathways

    JAK-STAT Signalweg, Hormone Activity, Negative Regulation of intrinsic apoptotic Signaling, Negative Regulation of Transporter Activity
Sie sind hier:
Chat with us!