CD86 Protein (CD86) (His tag)

Produktnummer ABIN7320993

Recombinant CD86-Protein exprimiert in Human Cells.

Kurzübersicht für CD86 Protein (CD86) (His tag) (ABIN7320993)

Target: CD86

Protein-Typ: Recombinant

Spezies: Kaninchen

Quelle: Human Cells

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Produktdetails

Aufreinigungstag / Konjugat: Dieses CD86 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Rabbit B7-2/CD86 Protein (His Tag)

Sequenz: Ala23-Arg246

Produktmerkmale: Recombinant Rabbit CD86 is produced by our Mammalian expression system and the target gene encoding Ala23-Arg246 is expressed with a 6His tag at the C-terminus.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: CD86

Andere Bezeichnung: B7-2/CD86

Hintergrund:

Background: T-lymphocyte activation antigen CD86 (B7-2) is a glycosylated protein in the B7 family. B7 family members are transmembrane cell surface molecules that play important roles in immune activation and the maintenance of immune tolerance. It is highly expressed on activated antigen presenting cells. CD86 involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. It may play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. It is expressed by activated B-lymphocytes and monocytes and promoted by MARCH8 and results in endocytosis and lysosomal degradation.

Synonym: T-lymphocyte activation antigen CD86, Activation B7-2 antigen, CD86

Molekulargewicht: 26.3 kDa

UniProt: P42071

Pathways: T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation