CPE Protein (His tag)

Produktnummer ABIN7318246

Dieses Recombinant CPE-Protein wird in Human Cells exprimiert.

Kurzübersicht für CPE Protein (His tag) (ABIN7318246)

Target: CPE (Carboxypeptidase E (CPE))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Human Cells

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Produktdetails

Aufreinigungstag / Konjugat: Dieses CPE Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human Carboxypeptidase E/CPE Protein (His Tag)

Sequenz: Arg42-Ser453

Produktmerkmale: Recombinant Human Carboxypeptidase E is produced by our Mammalian expression system and the target gene encoding Arg42-Ser453 is expressed with a 6His tag at the C-terminus.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Frozen, Liquid

Buffer: Supplied as a 0.2 μm filtered solution of 20 mM TrisHCl,150 mM NaCl,1 mM ZnCl2,10 % Glycerol, pH 7.5.

Lagerung: -20 °C

Informationen zur Lagerung: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Antigendetails

Target: CPE (Carboxypeptidase E (CPE))

Andere Bezeichnung: Carboxypeptidase E/CPE

Hintergrund:

Background: The active form of CPE cleaves C-terminal amino acid residues of the peptide, and is thus involved in the biosynthesis of peptide hormones and neurotransmitters including insulin, enkephalin, etc. It is thought that membrane-associated CPE acts as a sorting receptor for targeting regulated secretory proteins which are mostly prohormones and neuropeptides in the trans-Golgi network of the pituitary and in secretory granules into the secretory pathway. Defects in this protein are implicated in type II diabetes due to impaired glucose clearance and insulin resistance.

Synonym: Carboxypeptidase E(CPE for short), Carboxypeptidase H, Enkephalin convertase, Prohormone-processing carboxypeptidase

Molekulargewicht: 47.1 kDa

UniProt: P16870

Pathways: Peptide Hormone Metabolism, Synaptic Membrane