14-3-3 theta Protein (YWHAQ) (GST tag)

Produktnummer ABIN7317745

Dieses Recombinant 14-3-3 theta-Protein wird in Escherichia coli (E. coli) produziert.

Kurzübersicht für 14-3-3 theta Protein (YWHAQ) (GST tag) (ABIN7317745)

Target: 14-3-3 theta (YWHAQ)

Protein-Typ: Recombinant

Spezies: Human

Quelle: Escherichia coli (E. coli)

Reinheit: > 88 % as determined by reducing SDS-PAGE.

Produktdetails

Aufreinigungstag / Konjugat: Dieses 14-3-3 theta Protein ist gelabelt mit GST tag.

Verwendungszweck: Recombinant Human 14-3-3 tau/14-3-3 theta/YWHAQ Protein (GST Tag)

Sequenz: Met 1-Asn 245

Produktmerkmale: A DNA sequence encoding the human YWHAQ (P27348) (Met 1-Asn 245) was fused with the GST tag at the N-terminus.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 20 mM Tris, 0.15m NaCl, 20 mM GSH, pH 7.5

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: 14-3-3 theta (YWHAQ)

Andere Bezeichnung: 14-3-3 tau/14-3-3 theta/YWHAQ

Hintergrund:

Background: G protein-coupled receptor kinase 5, also known as G protein-coupled receptor kinase GRK5 and GRK5, is a member of the protein kinase superfamily, AGC Ser/Thr protein kinase family and GPRK subfamily. GRKs specifically phosphorylate agonist-occupied G protein-coupled receptors at the inner surface of the plasma membrane (PM), leading to receptor desensitization. GRKs utilize a variety of mechanisms to bind tightly, and sometimes reversibly, to cellular membranes. GRKs play an important role in mediating agonist-specific desensitization of numerous G protein-coupled receptors. GRK5 contains one AGC-kinase C-terminal domain, one protein kinase domain and one RGS domain. GRK5 specifically phosphorylates the activated forms of G protein-coupled receptors. Phospholipid-stimulated autophosphorylation may represent a novel mechanism for membrane association and regulation of GRK5 activity. GRK5 deficiency significantly exaggerates microgliosis and astrogliosis in the presence of an inflammatory initiator, such as the excess fibrillar Abeta and the subsequent active inflammatory reactions. GRK5 deficiency has been linked to early Alzheimer's disease in humans and mouse models of the disease.

Synonym: 1C5;41701;HS1

Molekulargewicht: 54.6 kDa

UniProt: P27348

Pathways: Apoptose, Myometrial Relaxation and Contraction