IL-13 Protein (His tag)

Produktnummer ABIN7121398

Recombinant IL-13-Protein exprimiert in HEK-293 Cells.

Kurzübersicht für IL-13 Protein (His tag) (ABIN7121398)

Target: IL-13 (IL13) (Interleukin 13 (IL13))

Protein-Typ: Recombinant

Spezies: Hund

Quelle: HEK-293 Cells

Reinheit: >90 % as determined by SDS-PAGE.

Produktdetails

Aufreinigungstag / Konjugat: Dieses IL-13 Protein ist gelabelt mit His tag.

Verwendungszweck: Canine IL-13 Protein, His Tag

Sequenz: Ser 19 - Arg 131

Produktmerkmale: Canine IL-13, His Tag (IL3-C52H4) is expressed from human 293 cells (HEK293). It contains AA Ser 19 - Arg 131 (Accession # NP_001003384.1).

Endotoxin-Niveau: Less than 1.0 EU per μg by the LAL method.

Anwendungsinformationen

Applikationshinweise: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 14.3 kDa. The protein migrates as 30-35 kDa under reducing (R) condition due to glycosylation.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: PBS, pH 7.4

Lagerung: -20 °C

Informationen zur Lagerung: -20°C

Antigendetails

Target: IL-13 (IL13) (Interleukin 13 (IL13))

Andere Bezeichnung: IL-13

Hintergrund: Synonyms: IL13,ALRH,BHR1,MGC116786,MGC116788,MGC116789,P600,Interleukin-13,
Description: Interleukin 13 (IL13) is also known as ALRH, BHR1and P600, is a single-chain glycosylated polypeptide, and is a cytokine critical in regulating inflammatory and immune responses. IL13 is secreted by many cell types, but especially by T helper type 2 (Th2) cells. IL-13 induces its effects through a multi-subunit receptor that includes the alpha chain of the IL-4 receptor (IL-4Rα) and at least one of two known IL-13-specific binding chains. The functions of IL-13 overlap considerably with those of IL-4, especially with regard to changes induced on hematopoietic cells, but these effects are probably less important given the more potent role of IL-4. IL-13 induces matrix metalloproteinases (MMPs) as part of a mechanism that protects against excessive allergic inflammation that predisposes to asphyxiation. IL-13 induces many features of allergic lung disease, including airway hyperresponsiveness, goblet cell metaplasia and mucus hypersecretion, which all contribute to airway obstruction.

Molekulargewicht: 14.3 kDa

NCBI Accession: NP_001003384

Pathways: JAK-STAT Signalweg, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Proton Transport