PD-L1 Protein (His tag)

Produktnummer ABIN7121291

Dieses Recombinant PD-L1-Protein wird in HEK-293 Cells produziert.

Kurzübersicht für PD-L1 Protein (His tag) (ABIN7121291)

Target: PD-L1 (CD274 (PD-L1))

Protein-Typ: Recombinant

Spezies: Hund

Quelle: HEK-293 Cells

Reinheit: >90 % as determined by SDS-PAGE.

Güteklasse: MALS verified

Produktdetails

Aufreinigungstag / Konjugat: Dieses PD-L1 Protein ist gelabelt mit His tag.

Verwendungszweck: Canine PD-L1 / B7-H1 Protein, His Tag (MALS verified)

Sequenz: Phe 19 - Arg 236

Produktmerkmale: Canine PD-L1, His Tag (PDL-C52H4) is expressed from human 293 cells (HEK293). It contains AA Phe 19 - Arg 236 (Accession # E2RKZ5-1).

Endotoxin-Niveau: Less than 1.0 EU per μg by the LAL method.

Anwendungsinformationen

Applikationshinweise: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 26.6 kDa. The protein migrates as 35-50 kDa under reducing (R) condition due to glycosylation.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: PBS, pH 7.4

Lagerung: -20 °C

Informationen zur Lagerung: -20°C

Antigendetails

Target: PD-L1 (CD274 (PD-L1))

Andere Bezeichnung: PD-L1 / B7-H1

Hintergrund: Synonyms: PD-L1,CD274,B7-H1,PDCD1L1,PDCD1LG1,
Description: Programmed cell death 1 ligand 1 (PDL1) is also known as B7-H, B7H1, MGC142294, MGC142296, PD-L1, PDCD1L1 and PDCD1LG1,which is a member of the growing B7 family of immune molecules and is involved in the regulation of cellular and humoral immune responses.PDL1 is a cell surface immunoglobulin superfamily with two Ig-like domains within the extracellular region and a short cytoplasmic domain. This protein is broadly expressed in the majority of peripheral tissues as well as hematopoietic cells. Interaction between PDL1 and its receptors belonging to the CD28 family of molecules provide both stimulatory and inhibitory signals in regulating T cell activation and tolerance. PDL1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression.

Molekulargewicht: 26.6 kDa

NCBI Accession: NP_001278901

Pathways: Cancer Immune Checkpoints