IL21 Receptor Protein (AA 20-232) (mFc Tag)

Produktnummer ABIN7092744

Produktdetails

Target: IL21 Receptor (IL21R) (Interleukin 21 Receptor (IL21R))

Protein-Typ: Recombinant

Proteineigenschaft: AA 20-232

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses IL21 Receptor Protein ist gelabelt mit mFc Tag.

Verwendungszweck: Recombinant Human IL21R with C-terminal mouse Fc tag

Spezifität: IL21R (Cys20-Glu232) mFc (Pro99-Lys330)

Produktmerkmale: Extracellular Domain Protein

Aufreinigung: Purified from cell culture supernatant by affinity chromatography

Reinheit: The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Haltbarkeit: 12 months

Antigendetails

Target: IL21 Receptor (IL21R) (Interleukin 21 Receptor (IL21R))

Andere Bezeichnung: IL21R (IL21R Produkte)

Hintergrund: The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2, 4, 7, 9, and 15. This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants have been described.

Molekulargewicht: predicted molecular mass of 50.7 kDa after removal of the signal peptide.The apparent molecular mass of IL21R-mFc is 55-70 kDa due to glycosylation.

UniProt: Q9HBE5

Pathways: JAK-STAT Signalweg