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IL21 Receptor Produkte

(Interleukin 21 Receptor (IL21R))
The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2, 4, 7, 9, and 15. This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2010].

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Ausgewählte IL21 Receptor Kategorien

IL21 Receptor Antikörper

High quality antibodies with extensive validation data.

IL21 Receptor ELISA Kits

Reliable ELISA kits for a wide range of species.

IL21 Receptor Proteine

Proteins for various applications incl. WB, ELISA, IF etc.

Empfohlene IL21 Receptor Antikörper

Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Applikation ELISA, IHC, WB
Validierungen
  • (3)
Kat. Nr. ABIN7156852
Menge 100 μL
Datenblatt Datenblatt
Reaktivität Human
Applikation ELISA, FM, IHC, WB
Validierungen
  • (3)
Kat. Nr. ABIN6656222
Menge 100 μg
Datenblatt Datenblatt
Reaktivität Human
Applikation ICC, IHC, WB
Validierungen
  • (2)
Kat. Nr. ABIN1868630
Menge 100 μL
Datenblatt Datenblatt

Empfohlene IL21 Receptor ELISA Kits

Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Analytical Method Quantitative Sandwich ELISA
Validierungen
  • (1)
Kat. Nr. ABIN6957098
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Human
Analytical Method Quantitative Sandwich ELISA
Validierungen
Kat. Nr. ABIN625319
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Human
Analytical Method Semi-Quantitative Sandwich ELISA
Validierungen
Kat. Nr. ABIN6384626
Menge 96 tests
Datenblatt Datenblatt

Empfohlene IL21 Receptor Proteine

Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Cynomolgus
Source HEK-293 Cells
Validierungen
  • (3)
Kat. Nr. ABIN7275007
Menge 100 μg
Datenblatt Datenblatt
Reaktivität Human
Source HEK-293 Cells
Validierungen
  • (2)
Kat. Nr. ABIN2181372
Menge 200 μg
Datenblatt Datenblatt
Reaktivität Rat
Source HEK-293 Cells
Validierungen
  • (1)
Kat. Nr. ABIN7196500
Menge 50 μg
Datenblatt Datenblatt

Neueste Publikationen zu unseren IL21 Receptor Produkten

Sekiguchi, Nomoto, Nagata, Kiyota, Fukuda, Yamada, Takezako, Kobayashi: "Gene Expression Profile Signature of Aggressive Waldenström Macroglobulinemia with Chromosome 6q Deletion." in: BioMed research international, Vol. 2018, pp. 6728128, (2019) (PubMed).

Linnebacher, Mayer, Marnet, Bergmann, Herpel, Revia, Yin, Liu, Hackert, Giese, Herr, Gaida: "Interleukin 21 Receptor/Ligand Interaction Is Linked to Disease Progression in Pancreatic Cancer." in: Cells, Vol. 8, Issue 9, (2019) (PubMed).

Zhang, Kiapour, Kapoor, Khan, Thamilarasan, Tao, Cohen, Miller, Sobel, Markovic-Plese: "IL-11 Induces Encephalitogenic Th17 Cells in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 203, Issue 5, pp. 1142-1150, (2019) (PubMed).

Dinesh, Rasool et al.: "Berberine inhibits IL-21/IL-21R mediated inflammatory proliferation of fibroblast-like synoviocytes through the attenuation of PI3K/Akt signaling pathway and ameliorates IL-21 mediated ..." in: Cytokine, Vol. 106, pp. 54-66, (2018) (PubMed).

Guan, Wang, Meng, Shi, Jiang, Xiao, Shi, Xu, Zhang: "Increased IL-21/IL-21R expression and its proinflammatory effects in autoimmune thyroid disease." in: Cytokine, Vol. 72, Issue 2, pp. 160-5, (2015) (PubMed).

Zhang, Tao, Chopra, Dujmovic-Basuroski, Jin, Tang, Drulovic, Markovic-Plese: "IL-11 Induces Th17 Cell Responses in Patients with Early Relapsing-Remitting Multiple Sclerosis." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 194, Issue 11, pp. 5139-49, (2015) (PubMed).

Kaltenmeier, Gawanbacht, Beyer, Lindner, Trzaska, van der Merwe, Härter, Grüner, Fabricius, Lotfi, Schwarz, Schütz, Hönig, Schulz, Kern, Bommer, Schrezenmeier, Kirchhoff, Jahrsdörfer: "CD4+ T cell-derived IL-21 and deprivation of CD40 signaling favor the in vivo development of granzyme B-expressing regulatory B cells in HIV patients." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 194, Issue 8, pp. 3768-77, (2015) (PubMed).

Biswas, Gupta, Stirzaker, Kumar, Jessberger, Lu, Bhagat, Pernis: "Dual regulation of IRF4 function in T and B cells is required for the coordination of T-B cell interactions and the prevention of autoimmunity." in: The Journal of experimental medicine, Vol. 209, Issue 3, pp. 581-96, (2012) (PubMed).

Liu, Yang, Ma, Wang, Huang, Zhang, Chen, Wu: "Interleukin-21 induces the differentiation of human Tc22 cells via phosphorylation of signal transducers and activators of transcription." in: Immunology, Vol. 132, Issue 4, pp. 540-8, (2011) (PubMed).

Sarra, Caruso, Cupi, Monteleone, Stolfi, Campione, Diluvio, Mazzotta, Botti, Chimenti, Costanzo, MacDonald, Pallone, Monteleone: "IL-21 promotes skin recruitment of CD4(+) cells and drives IFN-?-dependent epidermal hyperplasia." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 186, Issue 9, pp. 5435-42, (2011) (PubMed).

Synonyme und alternative Namen zu IL21 Receptor

interleukin 21 receptor (IL21R), interleukin 21 receptor, tandem duplicate 1 (il21r.1), interleukin 21 receptor (Il21r), CD360, il-21ra.a, IL21R, NILR

Bezeichner auf Proteinebene für IL21 Receptor

  • interleukin-21 receptor
  • interleukin 21 receptor
  • interleukin 21 receptor alpha.a
  • IL-21 receptor
  • novel interleukin receptor
  • IL-21R
  • LR-beta
  • NR8
  • lymphocyte receptor beta
  • novel cytokine receptor 8
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