IL21 Receptor Antikörper (AA 20-232)

Produktnummer ABIN7193230

Produktdetails anti-IL21 Receptor Antikörper

Target: IL21 Receptor (IL21R) (Interleukin 21 Receptor (IL21R))

Bindungsspezifität: AA 20-232

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser IL21 Receptor Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunocytochemistry (ICC), Neutralization (Neut)

Aufreinigung: purified

Immunogen: Purified recombinant fragment of human CD360 (AA: extra 20-232) expressed in E. coli.

Klon: 8H10G4D12

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: ELISA: 1:10000, WB: 1:500 - 1:2000, FCM: 1:200 - 1:400, ICC: N/A, IHC: N/A

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Purified antibody in PBS with 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: 4°C, -20°C for long term storage

Details zu IL21 Receptor

Target: IL21 Receptor (IL21R) (Interleukin 21 Receptor (IL21R))

Andere Bezeichnung: CD360 (IL21R Produkte)

Synonyme: IL21R antikoerper, il-21ra.a antikoerper, CD360 antikoerper, NILR antikoerper, interleukin 21 receptor antikoerper, interleukin 21 receptor, tandem duplicate 1 antikoerper, IL21R antikoerper, il21r.1 antikoerper, Il21r antikoerper

Hintergrund:

Description: The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2, 4, 7, 9, and 15. This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants have been described.

Aliases: IL21R, NILR, IMD56

Molekulargewicht: 59.1 kDa

Gen-ID: 50615

Pathways: JAK-STAT Signalweg