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Glypican 3 Protein (GPC3) (Fc Tag)

Dieses Recombinant Glypican 3-Protein wird in HEK-293 Cells exprimiert.
Produktnummer ABIN7092674

Kurzübersicht für Glypican 3 Protein (GPC3) (Fc Tag) (ABIN7092674)

Target

Alle Glypican 3 (GPC3) Proteine anzeigen
Glypican 3 (GPC3)

Protein-Typ

Recombinant

Spezies

  • 22
  • 9
  • 9
  • 4
  • 1
Human

Quelle

  • 28
  • 9
  • 3
  • 1
  • 1
  • 1
  • 1
  • 1
HEK-293 Cells

Reinheit

The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
  • Aufreinigungstag / Konjugat

    Dieses Glypican 3 Protein ist gelabelt mit Fc Tag.

    Verwendungszweck

    Recombinant Human GPC3 Protein with N-terminal Human Fc tag

    Spezifität

    HFc (Glu99-Ala330) GPC3 (Asp511-Ser560)

    Produktmerkmale

    Extracellular Domain Protein

    Aufreinigung

    Purified from cell culture supernatant by affinity chromatography
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  • Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Buffer

    Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

    Lagerung

    -20 °C,-80 °C

    Informationen zur Lagerung

    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

    Haltbarkeit

    12 months
  • Target

    Glypican 3 (GPC3)

    Andere Bezeichnung

    GPC3

    Hintergrund

    Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The protein encoded by this gene can bind to and inhibit the dipeptidyl peptidase activity of CD26, and it can induce apoptosis in certain cell types. Deletion mutations in this gene are associated with Simpson-Golabi-Behmel syndrome, also known as Simpson dysmorphia syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009] References: Fu Ying, Urban Daniel J, Nani Roger R et al. Glypican-3-Specific Antibody Drug Conjugates Targeting Hepatocellular Carcinoma.[J] .Hepatology, 2019, 70: 563-576. Zhang Yi-Fan, Ho Mitchell, Humanization of high-affinity antibodies targeting glypican-3 in hepatocellular carcinoma.[J] .Sci Rep, 2016, 6: 33878.

    Molekulargewicht

    predicted molecular mass of 43.3 kDa after removal of the signal peptide.

    UniProt

    P51654

    Pathways

    Glycosaminoglycan Metabolic Process
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