K-RAS Protein (AA 1-169) (His tag)

Produktnummer ABIN7013192

Produktdetails

Target: K-RAS (KRAS) (GTPase Kras (KRAS))

Protein-Typ: Recombinant

Proteineigenschaft: AA 1-169

Spezies: Human

Quelle: Insektenzellen

Aufreinigungstag / Konjugat: Dieses K-RAS Protein ist gelabelt mit His tag.

Produktmerkmale: Human KRAS Protein, His Tag

Reinheit: >90 % as determined by SDS-PAGE.

Endotoxin-Niveau: Less than 1.0 EU per μg by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 50 mM Tris, 0.5 M NaCl, pH 7.5

Lagerung: -20 °C

Antigendetails

Target: K-RAS (KRAS) (GTPase Kras (KRAS))

Andere Bezeichnung: KRAS (KRAS Produkte)

Substanzklasse: Viral Protein

Hintergrund: KRAS (Kirsten rat sarcoma 2 viral oncogene homolog) gene is a proto-oncogene that encodes a small GTPase transductor protein called KRAS. KRAS is also known as Ki-Ras, c-K-ras and c-Ki-ras. Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation, promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner. RAS is one of the most frequently mutated oncogenes in human cancer but the frequency and distribution of RAS gene mutations are not uniform. In details, mutation of glycine 12 (G12) causes RAS activation by interfering with GAP binding and GAP-stimulated GTP hydrolysis. The reference shows the pathway may as a potential therapy targets.

Molekulargewicht: 21.3 kDa

NCBI Accession: NP_004976