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SARS-CoV-2 Spike S1 protein (His tag) Protein

Spezies: SARS Coronavirus-2 (SARS-CoV-2) Quelle: HEK-293 Cells >90 % as determined by SDS-PAGE. Func, SDS
Pubmed (1)
Produktnummer ABIN6952427
$418.00
Zzgl. Versandkosten $45.00
100 μg ABIN6952427
100 μg ABIN6952427
local_shipping Lieferung nach: Vereinigte Staaten von Amerika
Lieferung in 2 bis 3 Werktagen
  • Proteinname
    Spezies
    SARS Coronavirus-2 (SARS-CoV-2)
    Quelle
    HEK-293 Cells
    Aufreinigungstag / Konjugat
    Dieses SARS-CoV-2 Spike S1 Protein ist gelabelt mit His tag.
    Applikation
    Functional Studies (Func), SDS-PAGE (SDS)
    Produktmerkmale
    This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 76.9 kDa. The protein migrates as 100-140 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
    AA 16-685
    Reinheit
    >90 % as determined by SDS-PAGE.
    Endotoxin-Niveau
    Less than 1.0 EU per μg by the LAL method.
    Biological Activity Comment
    Immobilized 2019-nCoV S1 protein, His Tag at 2 μg/mL (100 μL/well) can bind Human ACE2, Fc Tag with a linear range of 2-20 ng/mL (QC tested).
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Buffer
    Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally trehalose is added as protectant before lyophilization.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    -20°C
  • Christopher Minteer, Arnau Casanovas-Massana, Tao Li, David McDonald, Linda Wang, Si Hui Pan, David Caianiello, Jesse Collinski, Edward deRamon, Robert Hale, Rebecca Howell, Jason Ray, Joseph Vinetz, Morgan Levine, Albert Ko, David Spiegel: "Multi-site Validation of a SARS-CoV-2 IgG/IgM Rapid Antibody Detection Kit" in: bioRxiv, 2020

  • Proteinname
    Hintergrund
    S1 protein, Spike glycoprotein Subunit1, S glycoprotein Subunit1, Spike protein S1
    Protein S (PROS1) is glycoprotein and expressed in many cell types supporting its reported involvement in multiple biological processes that include coagulation, apoptosis, cancer development and progression, and the innate immune response. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2, DPP4, CEACAM etc.. It's been reported that 2019-nCoV can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.
    Molekulargewicht
    76.9 kDa
    Gen-ID
    43740568
    UniProt
    P0DTC2
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