MAPT Protein

Produktnummer ABIN6700611

Hersteller Produkt- Nr.: 009-001-t74s

Produktdetails

Target: MAPT (Microtubule-Associated Protein tau (MAPT))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Escherichia coli (E. coli)

Applikation: Western Blotting (WB)

Hersteller Produkt- Nr.: 009-001-t74s

Hersteller: Rockland

Verwendungszweck: Tau-381 recombinant protein

Aufreinigung: Recombinant full-length human tag-free Tau-381 was expressed in E. coli cells. The purity was determined to be >90% by densitometry.

Reinheit: >90%

Anwendungsinformationen

Applikationshinweise:

Application Note: Tau-381 Protein is stored in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM PMSF, 25 % glycerol. Tau-381 Protein is suitable for use in Western Blot and Kinase Assay. Expect a band approximately ~54 kDa on specific lysates or tissues. Specific conditions for reactivity should be optimized by the end user.

Western Blot Dilution: User Optimized

Other: Kinase Assay-User Optimized

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.2 μg/μL

Buffer: Tau-381 Protein is stored in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM PMSF, 25 % glycerol.

Lagerung: -80 °C

Informationen zur Lagerung: Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Haltbarkeit: 12 months

Antigendetails

Target: MAPT (Microtubule-Associated Protein tau (MAPT))

Andere Bezeichnung: MAPT (MAPT Produkte)

Hintergrund:

Synonyms: Tau-B, (N1R3), MAPT, MSTD, PPND, DDPAC, MAPTL, MTBT1, MTBT2, FTDP-17, FLJ31424, MGC138549, Microtubule-associated protein tau

Background: Tau-381 or Tau-B is a member of the Tau family of proteins which function to stabilize the microtubules by binding to them. Tau proteins are subject to phosphorylation and this phenomenon regulates the association of the Tau protein with the microtubules (1). Deposits of Alzheimer's disease AD-associated proteins, such as hyperphosphorylated Tau, as well as other shared misfolded proteins, such as, β-amyloid precursor protein (βAPP), ubiquitin, and various chaperones and protein kinases are thought to play a pathologic role in the cognitive decline and muscular failure. Malfunctioning of Tau proteins is associated with microtubules disintegration and collapsing of the neuronal transport system (2). Tau-381 Protein is ideal for investigators involved in Signaling Proteins, Tau Proteins, Invasion/Metastasis, Neurobiology, and p38 Pathway research.

UniProt: P10636-4

Pathways: MAPK Signalweg, Microtubule Dynamics, M Phase, Regulation of Cell Size