CLCF1 Protein (AA 28-225) (His tag)

Produktnummer ABIN667531

Produktdetails

Target: CLCF1 (Cardiotrophin-Like Cytokine Factor 1 (CLCF1))

Protein-Typ: Recombinant

Proteineigenschaft: AA 28-225

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses CLCF1 Protein ist gelabelt mit His tag.

Applikation: SDS-PAGE (SDS)

Produktmerkmale: CLCF1, 28-225aa, Human, His tag, E.coli

Reinheit: > 90 % by SDS - PAGE

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/ml (determined by Bradford assay)

Buffer: Liquid. 20mM sodium citrate (pH 3.5), 0.4M Urea, 10% glycerol

Lagerung: 4 °C

Antigendetails

Target: CLCF1 (Cardiotrophin-Like Cytokine Factor 1 (CLCF1))

Andere Bezeichnung: CLCF1 (CLCF1 Produkte)

Hintergrund: CLCF1, also known as cardiotrophin-like cytokine factor 1, belongs to the interleukin 6 family of cytokines, which are involved in cell signaling through phosphorylation of gp130. CLCF1 has a sequence of 225-amino acids with a 27-aa signal peptide, a molecular mass of 22 kDa in mature form, and the highest homology to cardiotrophin-1 and ciliary neurotrophic factor. CLCF1 can be actively secreted from cells by forming a complex with soluble type I CRLF1 or soluble CNTFR. Defects in CLCF1 cause cold-induced sweating syndrome 2 (CISS2). This syndrome is characterized by a profuse sweating after exposure to cold as well as congenital physical abnormalities of the head and spine. Synonyms: Cardiotrophin-like cytokine factor 1, BSF-3, BSF3, CISS2, CLC, NNT-1, NNT1, NR6. NCBI no.: NP_037378

Molekulargewicht: 24.6 kDa (219aa)

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response