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CNTF Protein (AA 1-200)

CNTF Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant > 90 % by SDS - PAGE SDS Active
Produktnummer ABIN6387771
  • Target Alle CNTF Proteine anzeigen
    CNTF (Ciliary Neurotrophic Factor (CNTF))
    Protein-Typ
    Recombinant
    Biologische Aktivität
    Active
    Proteineigenschaft
    AA 1-200
    Spezies
    • 19
    • 8
    • 4
    • 2
    • 2
    • 2
    Human
    Quelle
    • 26
    • 3
    • 3
    • 2
    • 1
    Escherichia coli (E. coli)
    Applikation
    SDS-PAGE (SDS)
    Sequenz
    MAFTEHSPLT PHRRDLCSRS IWLARKIRSD LTALTESYVK HQGLNKNINL DSADGMPVAS TDQWSELTEA ERLQENLQAY RTFHVLLARL LEDQQVHFTP TEGDFHQAIH TLLLQVAAFA YQIEELMILL EYKIPRNEAD GMPINVGDGG LFEKKLWGLK VLQELSQWTV RSIHDLRFIS SHQTGIPARG SHYIANNKKM
    Reinheit
    > 90 % by SDS - PAGE
    Endotoxin-Niveau
    < 1.0 EU per 1 microgram of protein (determined by LAL method)
    Biological Activity Comment
    Measured in a cell proliferation assay using TF-1 human erythroleukemic cells. The ED50 for this effect is less than or equal to 500 ng/ml.
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    Discover our top product CNTF Protein
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    Origin
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    Konjugat His tag
    Origin Human
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    Origin Human
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  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Kommentare

    Bioactivity Validated

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Liquid. In 20  mM Tris-HCl buffer (  pH 8.0) containing 1  mM DTT, 10 % glycerol
    Lagerung
    4 °C,-20 °C,-80 °C
    Informationen zur Lagerung
    Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
  • Target
    CNTF (Ciliary Neurotrophic Factor (CNTF))
    Andere Bezeichnung
    CNTF (CNTF Produkte)
    Hintergrund
    CNTF (Ciliary neurotrophic factor) is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. This protein is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. CNTF protein is structurally related to leukemia inhibitory factor (LIF), interleukin-6 (IL-6), interleukin-11 (IL-11) and oncostatin M (OSM). It is localized in the cell nucleus subsequent to receptor binding. Recombinant human CNTF protein was expressed in E.coli and purified by using conventional chromatography techniques.
    Molekulargewicht
    22.9 kDa (200aa), confirmed by MALDI-TOF
    NCBI Accession
    NP_000605
    UniProt
    P26441
    Pathways
    JAK-STAT Signalweg
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