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CNTF Protein (AA 1-200)

Dieses Recombinant CNTF-Protein wird in Escherichia coli (E. coli) exprimiert.
Produktnummer ABIN6387771

Kurzübersicht für CNTF Protein (AA 1-200) (ABIN6387771)

Target

Alle CNTF Proteine anzeigen
CNTF (Ciliary Neurotrophic Factor (CNTF))

Protein-Typ

Recombinant

Biologische Aktivität

Active

Spezies

  • 19
  • 8
  • 4
  • 2
  • 2
  • 2
Human

Quelle

  • 26
  • 3
  • 3
  • 2
  • 1
Escherichia coli (E. coli)

Applikation

SDS-PAGE (SDS)

Reinheit

> 90 % by SDS - PAGE
  • Proteineigenschaft

    AA 1-200

    Sequenz

    MAFTEHSPLT PHRRDLCSRS IWLARKIRSD LTALTESYVK HQGLNKNINL DSADGMPVAS TDQWSELTEA ERLQENLQAY RTFHVLLARL LEDQQVHFTP TEGDFHQAIH TLLLQVAAFA YQIEELMILL EYKIPRNEAD GMPINVGDGG LFEKKLWGLK VLQELSQWTV RSIHDLRFIS SHQTGIPARG SHYIANNKKM

    Endotoxin-Niveau

    < 1.0 EU per 1 microgram of protein (determined by LAL method)

    Biological Activity Comment

    Measured in a cell proliferation assay using TF-1 human erythroleukemic cells. The ED50 for this effect is less than or equal to 500 ng/ml.
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  • Applikationshinweise

    Optimal working dilution should be determined by the investigator.

    Kommentare

    Bioactivity Validated

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 mg/mL

    Buffer

    Liquid. In 20  mM Tris-HCl buffer (  pH 8.0) containing 1  mM DTT, 10 % glycerol

    Lagerung

    4 °C,-20 °C,-80 °C

    Informationen zur Lagerung

    Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
  • Target

    CNTF (Ciliary Neurotrophic Factor (CNTF))

    Andere Bezeichnung

    CNTF

    Hintergrund

    CNTF (Ciliary neurotrophic factor) is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. This protein is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. CNTF protein is structurally related to leukemia inhibitory factor (LIF), interleukin-6 (IL-6), interleukin-11 (IL-11) and oncostatin M (OSM). It is localized in the cell nucleus subsequent to receptor binding. Recombinant human CNTF protein was expressed in E.coli and purified by using conventional chromatography techniques.

    Molekulargewicht

    22.9 kDa (200aa), confirmed by MALDI-TOF

    NCBI Accession

    NP_000605

    UniProt

    P26441

    Pathways

    JAK-STAT Signalweg
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