GRK2 Protein (AA 2-634, partial) (His tag)

Produktnummer ABIN5712097

Produktdetails

Target: GRK2 (ADRBK1) (Adrenergic, Beta, Receptor Kinase 1 (ADRBK1))

Protein-Typ: Recombinant

Proteineigenschaft: partial, AA 2-634

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses GRK2 Protein ist gelabelt mit His tag.

Applikation: SDS-PAGE (SDS)

Sequenz: ADLEAVLADV SYLMAMEKSK ATPAARASKK ILLPEPSIRS VMQKYLEDRG EVTFEKIFSQ KLGYLLFRDF CLNHLEEARP LVEFYEEIKK YEKLETEEER VARSREIFDS YIMKELLACS HPFSKSATEH VQGHLGKKQV PPDLFQPYIE EICQNLRGDV FQKFIESDKF TRFCQWKNVE LNIHLTMNDF SVHRIIGRGG FGEVYGCRKA DTGKMYAMKC

Aufreinigung: SDS-PAGE

Reinheit: > 90 %

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Lagerung: -80 °C,4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Antigendetails

Target: GRK2 (ADRBK1) (Adrenergic, Beta, Receptor Kinase 1 (ADRBK1))

Andere Bezeichnung: ARBK1 (ADRBK1 Produkte)

Hintergrund: Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of th. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner.

Molekulargewicht: 29.7 kDa

UniProt: P25098

Pathways: EGFR Signaling Pathway, Neurotrophin Signalübertragung, Regulation of G-Protein Coupled Receptor Protein Signaling, CXCR4-mediated Signaling Events, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma, Thromboxane A2 Receptor Signaling