PD-L1 Protein (partial) (Fc Tag)

Produktnummer ABIN5608343

Recombinant PD-L1-Protein exprimiert in HEK-293 Cells.

Kurzübersicht für PD-L1 Protein (partial) (Fc Tag) (ABIN5608343)

Target: PD-L1 (CD274 (PD-L1))

Protein-Typ: Recombinant

Spezies: Maus

Quelle: HEK-293 Cells

Applikation: Western Blotting (WB)

Reinheit: >95 % as determined by SDS-PAGE.

Produktdetails

Proteineigenschaft: partial

Aufreinigungstag / Konjugat: Dieses PD-L1 Protein ist gelabelt mit Fc Tag.

Sequenz: Phe 19 - Thr 238

Endotoxin-Niveau: Endotoxin level is less than 0.1 EU per ug by the LAL method.

Anwendungsinformationen

Applikationshinweise: This recombinant protein can be used for WB.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: PBS, pH 7.4

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C.

Antigendetails

Target: PD-L1 (CD274 (PD-L1))

Andere Bezeichnung: PD-L1

Hintergrund: Programmed cell death 1 ligand 1 (PDL1) is also known as B7-H, B7H1, MGC142294, MGC142296, PD-L1, PDCD1L1 and PDCD1LG1,which is a member of the growing B7 family of immune molecules and is involved in the regulation of cellular and humoral immune responses.PDL1 is a cell surface immunoglobulin superfamily with two Ig-like domains within the extracellular region and a short cytoplasmic domain. This protein is broadly expressed in the majority of peripheral tissues as well as hematopoietic cells. Interaction between PDL1 and its receptors belonging to the CD28 family of molecules provide both stimulatory and inhibitory signals in regulating T cell activation and tolerance. PDL1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression.

Molekulargewicht: 51.8 kDa

Gen-ID: 60533

UniProt: Q9EP73

Pathways: Cancer Immune Checkpoints