Ret Proto-Oncogene Protein (RET) (DYKDDDDK-His Tag)

Produktnummer ABIN5505759

Dieses Recombinant Ret Proto-Oncogene-Protein wird in HEK-293 Cells produziert.

Kurzübersicht für Ret Proto-Oncogene Protein (RET) (DYKDDDDK-His Tag) (ABIN5505759)

Target: Ret Proto-Oncogene (RET)

Protein-Typ: Recombinant

Spezies: Human

Quelle: HEK-293 Cells

Applikation: Antibody Production (AbP), Standard (STD)

Reinheit: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Produktdetails

Aufreinigungstag / Konjugat: Dieses Ret Proto-Oncogene Protein ist gelabelt mit DYKDDDDK-His Tag.

Produktmerkmale:

• Recombinant human Purified recombinant protein of human ret proto-oncogene (RET), with C-terminal DDK/His tag, expressed in human cells, 20 μg (C-term DDK/His tag) protein expressed in Human 293HEK cells.
• Produced with end-sequenced ORF clone

Aufreinigung: Purified

Anwendungsinformationen

Applikationshinweise: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Kommentare:

The tag is located at the C-terminal.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 50 μg/mL

Buffer: 1 x PBS, pH 7.4, 10 % glycerol.

Lagerung: -80 °C

Informationen zur Lagerung: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Antigendetails

Target: Ret Proto-Oncogene (RET)

Andere Bezeichnung: ret proto-oncogene

Hintergrund: This gene, a member of the cadherin superfamily, encodes one of the receptor tyrosine kinases, which are cell-surface molecules that transduce signals for cell growth and differentiation. This gene plays a crucial role in neural crest development, and it can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations in this gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their biological validity has not been confirmed.

Molekulargewicht: 70.5 kDa

NCBI Accession: NP_066124

Pathways: RTK Signalweg, Dopaminergic Neurogenesis, Regulation of Cell Size, Tube Formation