TIGIT Protein (AA 89-208) (His tag)

Produktnummer ABIN4949059

Produktdetails

Target: TIGIT (T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Proteineigenschaft: AA 89-208

Spezies: Cynomolgus, Rhesusaffen

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses TIGIT Protein ist gelabelt mit His tag.

Applikation: Functional Studies (Func)

Sequenz: AA 89-208

Produktmerkmale: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 15.2 kDa. The protein migrates as 20-23 kDa under reducing (R) condition (SDS-PAGE).

Reinheit: >90 % as determined by SDS-PAGE.

Endotoxin-Niveau: Less than 1.0 EU per μg by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: PBS, pH 7.4

Handhabung: Please avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Antigendetails

Target: TIGIT (T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT))

Andere Bezeichnung: TIGIT (TIGIT Produkte)

Hintergrund: T-cell immunoreceptor with Ig and ITIM domains (TIGIT) is also known as V-set and immunoglobulin domain-containing protein 9 (VSIG9), V-set and transmembrane domain-containing protein 3 (VSTM3),which belongs to single-pass type I membrane protein containing an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM). TIGIT is expressed at low levels on peripheral memory and regulatory CD4+ T-cells and NK cells and is up-regulated following activation of these cells (at protein level). TIGIT binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.

Molekulargewicht: 15.2 kDa

NCBI Accession: XP_015300911

UniProt: G7NXM4

Pathways: Cancer Immune Checkpoints