PLG Protein
Kurzübersicht für PLG Protein (ABIN2830498)
Target
Alle PLG Proteine anzeigenProtein-Typ
Biologische Aktivität
Spezies
Quelle
Applikation
Reinheit
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Sequenz
- VYLSECKTGN GKNYRGTMSK TKNGITCQKW SSTSPHRPRF SPATHPSEGL EENYCRNPDN DPQGPWCYTT DPEKRYDYCD ILECEEECMH CSGENYDGKI SKTMSGLECQ AWDSQSPHAH GYIPSKFPNK NLKKNYCRNP DRELRPWCFT TDPNKRWELC DIPRCTTPPP SSGPTYQCLK GTGENYRGNV AVTVSGHTCQ HWSAQTPHTH NRTPENFPCK NLDENYCRNP DGKRAPWCHT TNSQVRWEYC KIPSCDSSP
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Produktmerkmale
- Biological Activity: Fully biologically active when compared to standard. The specific activity determined by an assay on anti-proliferation and anti-migration using endothelial cells in vitro and anti-angiogenesis in vivo is 5.5 x 105 IU/mg.
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Sterilität
- 0.2 μm filtered
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Plasminogen (PLG) (AA 98-356) protein (His tag)
PLG Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Plasminogen (PLG) (AA 1-810) protein (GST tag)PLG Spezies: Human Wirt: Wheat germ Recombinant WB, ELISA, AP, AA
Plasminogen (PLG) (AA 100-352) protein (His tag)PLG Spezies: Human Wirt: Yeast (Pichia pastoris) Recombinant > 95 % WB, SDS, ELISA, IP
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Lyophilized
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Buffer
- 20 mM NaAc, pH 5.5, 4 % mannitol
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Lagerung
- -20 °C
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- PLG (Plasminogen (PLG))
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Andere Bezeichnung
- PLG
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Hintergrund
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Relevance: Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells. {ECO:0000269|PubMed:14699093}., Angiostatin is an angiogenesis inhibitor that blocks neovascularization and growth of experimental primary and metastatic tumors in vivo. {ECO:0000269|PubMed:14699093}.
Synonyms: EC 3.4.21.7, -
Molekulargewicht
- 29.7 kDa
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UniProt
- P00747
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Pathways
- Komplementsystem, Lipid Metabolism
Target
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