Sonic Hedgehog Protein (SHH) (AA 25-198, C25I)
Kurzübersicht für Sonic Hedgehog Protein (SHH) (AA 25-198, C25I) (ABIN2816989)
Target
Alle Sonic Hedgehog (SHH) Proteine anzeigenProtein-Typ
Biologische Aktivität
Spezies
Quelle
Applikation
Reinheit
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Proteineigenschaft
- AA 25-198, C25I
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Sequenz
- Cys25 - Gly198 (Cys25Ile-Ile), with an N-terminal Met, Accession # Q62226
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Produktmerkmale
- Biological Activity: The ED50, as determined by inducing alkaline phosphatase production using murine C3H10T1/2 cells, is less than 300 ng/mL.
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Sterilität
- 0.2 μm filtered
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Sonic Hedgehog (SHH) (AA 25-198), (Cys25IleIle-Mutant) (Active) protein
SHH Spezies: Maus Wirt: Escherichia coli (E. coli) Recombinant > 95 % by SDS-PAGE and HPLC analyses. Active
Sonic Hedgehog (SHH) (AA 24-197), (Cys24IleIle-Mutant) (Active) proteinSHH Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant > 95 % by SDS-PAGE and HPLC analyses. Active
Sonic Hedgehog (SHH) protein (His tag)SHH Spezies: Maus Wirt: Human Cells Recombinant >95 % as determined by reducing SDS-PAGE.
Sonic Hedgehog (SHH) (Active) proteinSHH Spezies: Maus Wirt: Escherichia coli (E. coli) Recombinant > 95 % as determined by SDS-PAGE Active
Sonic Hedgehog (SHH) (AA 181-280) protein (GST tag)SHH Spezies: Human Wirt: Wheat germ Recombinant WB, ELISA, AP, AA
Sonic Hedgehog (SHH) protein (His tag)SHH Spezies: Human Wirt: HEK-293 Cells Recombinant Greater than 95 % as determined by reducing SDS-PAGE.
Sonic Hedgehog (SHH) (Active) protein (His tag)SHH Spezies: Maus Wirt: HEK-293 Cells Recombinant > 90 % as determined by SDS-PAGE Active
Sonic Hedgehog (SHH) (AA 25-198) protein (His tag)SHH Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant > 95 % by SDS-PAGE SDS
Sonic Hedgehog (SHH) proteinSHH Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant 97,00% SDS
Sonic Hedgehog (SHH) (AA 24-197) protein (His tag)SHH Spezies: Human Wirt: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Lyophilized
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Buffer
- 20 mM PB, pH 7.4, 150 mM NaCl
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Lagerung
- -20 °C
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- Sonic Hedgehog (SHH)
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Andere Bezeichnung
- Shh
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Hintergrund
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Relevance: Intercellular signal essential for a variety of patterning events during development: signal produced by the notochord that induces ventral cell fate in the neural tube and somites, and the polarizing signal for patterning of the anterior-posterior axis of the developing limb bud. Displays both floor plate- and motor neuron-inducing activity. The threshold concentration of N-product required for motor neuron induction is 5-fold lower than that required for floor plate induction. Activates the transcription of target genes by interacting with its receptor PTCH1 to prevent normal inhibition by PTCH1 on the constitutive signaling activity of SMO. {ECO:0000269|PubMed:14687547, ECO:0000269|PubMed:7736596}.
Synonyms: SHH, , Sonic hedgehog protein C-product Sonic hedgehog protein 27 kDa product,], -
Molekulargewicht
- 19.9 kDa
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UniProt
- Q62226
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Pathways
- Hedgehog Signalweg, Dopaminergic Neurogenesis, Regulation of Muscle Cell Differentiation, Tube Formation, Skeletal Muscle Fiber Development
Target
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