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Sonic Hedgehog (SHH) (AA 24-197) protein (His tag) Protein

SHH Spezies: Human Wirt: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE.
Pubmed (1 reference)
Produktnummer ABIN2181760
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  • Target Alle Sonic Hedgehog (SHH) Proteine anzeigen
    Sonic Hedgehog (SHH)
    Protein-Typ
    Recombinant
    Proteineigenschaft
    AA 24-197
    Spezies
    • 13
    • 10
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Quelle
    • 20
    • 18
    • 2
    • 1
    • 1
    • 1
    HEK-293 Cells
    Aufreinigungstag / Konjugat
    Dieses Sonic Hedgehog Protein ist gelabelt mit His tag.
    Sequenz
    AA 24-197
    Produktmerkmale
    This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 20.4 kDa. The protein migrates as 22 kDa under reducing (R) condition (SDS-PAGE).
    Reinheit
    >95 % as determined by SDS-PAGE.
    Sterilität
    0.22 μm filtered
    Endotoxin-Niveau
    Less than 1.0 EU per μg by the LAL method.
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Buffer
    PBS, pH 7.4
    Handhabung
    Please avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C-8 °C), After reconstitution under sterile conditions for 1 month (4 °C-8 °C) or 3 months (-20 °C to -70 °C).
  • Kaushal, Popli, Sankhwar, Shukla, Dwivedi: "Sonic hedgehog protects endometrial hyperplasial cells against oxidative stress via suppressing mitochondrial fission protein dynamin-like GTPase (Drp1)." in: Free radical biology & medicine, Vol. 129, pp. 582-599, (2018) (PubMed).

  • Target
    Sonic Hedgehog (SHH)
    Andere Bezeichnung
    Sonic Hedgehog (SHH Produkte)
    Synonyme
    HHG1, HLP3, HPE3, MCOPCB5, SMMCI, TPT, TPTPS, 9530036O11Rik, Dsh, Hhg1, Hx, Hxl3, M100081, fc83d08, shh, syu, vhh-1, vhh1, wu:fc83d08, Xhh, hedgehog, xshh, SHH, twh, twhh, sonic hedgehog, sonic hedgehog a, sonic hedgehog L homeolog, sonic hedgehog protein A, sonic hedgehog b, SHH, Shh, shha, shh.L, shh, shhb
    Hintergrund
    Sonic hedgehog protein (SHH) is also known as HHG-1, which belongs to the hedgehog family. SHH is expressed in fetal intestine, liver, lung, and kidney and not expressed in adult tissues. Sonic hedgehog protein can be cleavage into sonic hedgehog protein N-product and sonic hedgehog protein C-product by autolysis. SHH binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. In the absence of SHH, PTC represses the constitutive signaling activity of SMO. Also regulates another target, the gli oncogene. Intercellular signal essential for a variety of patterning events during development. The C-terminal domain displays an autoproteolysis activity and a cholesterol transferase activity. The N-product is the active species in both local and long-range signaling, whereas the C-product has no signaling activity.
    Molekulargewicht
    20.4 kDa
    NCBI Accession
    NP_000184
    Pathways
    Hedgehog Signalweg, Dopaminergic Neurogenesis, Regulation of Muscle Cell Differentiation, Tube Formation, Skeletal Muscle Fiber Development
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