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FZD5 Protein (Frizzled Family Receptor 5) (AA 27-180) (Fc Tag)

FZD5 Spezies: Human, Maus Wirt: HEK-293 Cells Recombinant >95 % (SDS-PAGE) SDS Active
Produktnummer ABIN2745685
$749.38
Zzgl. Versandkosten $45.00
3 x 50 μg
Lieferung in 5 bis 8 Werktagen
  • Target Alle FZD5 Proteine anzeigen
    FZD5 (Frizzled Family Receptor 5 (FZD5))
    Protein-Typ
    Recombinant
    Biologische Aktivität
    Active
    Proteineigenschaft
    AA 27-180
    Spezies
    Human, Maus
    Quelle
    • 4
    • 2
    • 1
    • 1
    HEK-293 Cells
    Aufreinigungstag / Konjugat
    Dieses FZD5 Protein ist gelabelt mit Fc Tag.
    Applikation
    SDS-PAGE (SDS)
    Spezifität
    Binds to human and mouse Wnt3a.
    Kreuzreaktivität
    Human, Maus
    Produktmerkmale
    The cysteine-rich domain (CRD) of human Frizzled-5 (aa 27-180) is fused at the C-terminus to the Fc portion of human IgG1.
    Reinheit
    >95 % (SDS-PAGE)
    Endotoxin-Niveau
    <0.01EU/μg purified protein (LAL test, Lonza).
  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Kommentare

    Inhibits Wnt3a activation in a stoechiometric manner.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Reconstitute with 50 μL sterile water.
    Konzentration
    Lot specific
    Buffer
    Lyophilized. Contains PBS.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Short Term Storage: +4°C
    Long Term Storage: -20°C
    Stable for at least 6 months after receipt when stored at -20°C.
    Haltbarkeit
    6 months
  • Target
    FZD5 (Frizzled Family Receptor 5 (FZD5))
    Andere Bezeichnung
    Frizzled-5 (FZD5 Produkte)
    Synonyme
    C2orf31, HFZ5, 5330434N09Rik, AI427138, Fz-5, Fz5, mFz5, Xfz5, frizzled5, frizzled5a, fz5, fzd5-A, fz2, fz8c, fzd8c, zg02, frizzled class receptor 5, frizzled class receptor 5 S homeolog, FZD5, Fzd5, fzd5.S, fzd5
    Hintergrund
    Wnts are lipid-modified morphogens that control many processes during development, stem cell maintenance and homeostasis and their aberrant regulation has been linked to diseases in man including diabetes, neurodegeneration and cancer. Three distinct receptor families mediate Wnt signaling: Fzs, the single-pass LRP5/6 co-receptors and the atypical tyrosine kinase receptors Ror2 and Ryk. Frizzled proteins can activate canonical Wnt/beta-catenin signaling as well as non-canonical pathways (Wnt/Ca2+ pathways and planar cell polarity). The cysteine-rich domain (CRD) of the frizzled receptors situated on the extracellular part of the receptor is sufficient to bind the Wnt ligands.
    Molekulargewicht
    ~50kDa (SDS-PAGE)
    UniProt
    Q13467
    Pathways
    WNT Signalweg
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