FZD5 Protein (AA 27-167) (Fc Tag)

Produktnummer ABIN2181128

Produktdetails

Target: FZD5 (Frizzled Family Receptor 5 (FZD5))

Protein-Typ: Recombinant

Proteineigenschaft: AA 27-167

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses FZD5 Protein ist gelabelt mit Fc Tag.

Sequenz: AA 27-167

Produktmerkmale: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 42.6 kDa. The protein migrates as 55-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Reinheit: >95 % as determined by SDS-PAGE.

Sterilität: 0.22 μm filtered

Endotoxin-Niveau: Less than 1.0 EU per μg by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: PBS, pH 7.4

Handhabung: Please avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).

Referenzen

Peterson, Nasarre, Bonilla, Hilliard, Samples, Morinelli, Hill, Klauber-DeMore: "Frizzled-5: a high affinity receptor for secreted frizzled-related protein-2 activation of nuclear factor of activated T-cells c3 signaling to promote angiogenesis." in: Angiogenesis, Vol. 20, Issue 4, pp. 615-628, (2018) (PubMed).

Antigendetails

Target: FZD5 (Frizzled Family Receptor 5 (FZD5))

Andere Bezeichnung: Frizzled-5 (FZD5 Produkte)

Synonyme: C2orf31 Protein, HFZ5 Protein, 5330434N09Rik Protein, AI427138 Protein, Fz-5 Protein, Fz5 Protein, mFz5 Protein, Xfz5 Protein, frizzled5 Protein, frizzled5a Protein, fz5 Protein, fzd5-A Protein, fz2 Protein, fz8c Protein, fzd8c Protein, zg02 Protein, frizzled class receptor 5 Protein, frizzled class receptor 5 S homeolog Protein, FZD5 Protein, Fzd5 Protein, fzd5.S Protein, fzd5 Protein

Hintergrund: Frizzled-5 (FZD5) is also known as FzE5, which belongs to the G-protein coupled receptor Fz/Smo family. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. FZD5 contains one FZ (frizzled) domain. FZD5 may be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. FZD5 interacts specifically with Wnt5A to induce the beta-catenin pathway. FZD5 interacts with GOPC.

Molekulargewicht: 42.6 kDa

UniProt: Q13467

Pathways: WNT Signalweg