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Frizzled Family Receptor 5 (FZD5) (AA 27-167) protein (Fc Tag) Protein

FZD5 Spezies: Human Wirt: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE.
Pubmed (1 reference)
Produktnummer ABIN2181128
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  • Target Alle FZD5 Proteine anzeigen
    FZD5
    Protein-Typ
    Recombinant
    Proteineigenschaft
    AA 27-167
    Spezies
    • 5
    • 4
    Human
    Quelle
    • 4
    • 2
    • 1
    • 1
    HEK-293 Cells
    Aufreinigungstag / Konjugat
    Dieses FZD5 Protein ist gelabelt mit Fc Tag.
    Sequenz
    AA 27-167
    Produktmerkmale
    This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 42.6 kDa. The protein migrates as 55-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
    Reinheit
    >95 % as determined by SDS-PAGE.
    Sterilität
    0.22 μm filtered
    Endotoxin-Niveau
    Less than 1.0 EU per μg by the LAL method.
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Buffer
    PBS, pH 7.4
    Handhabung
    Please avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
  • Peterson, Nasarre, Bonilla, Hilliard, Samples, Morinelli, Hill, Klauber-DeMore: "Frizzled-5: a high affinity receptor for secreted frizzled-related protein-2 activation of nuclear factor of activated T-cells c3 signaling to promote angiogenesis." in: Angiogenesis, Vol. 20, Issue 4, pp. 615-628, (2018) (PubMed).

  • Target
    FZD5
    Andere Bezeichnung
    Frizzled-5 (FZD5 Produkte)
    Synonyme
    C2orf31, HFZ5, 5330434N09Rik, AI427138, Fz-5, Fz5, mFz5, Xfz5, frizzled5, frizzled5a, fz5, fzd5-A, fz2, fz8c, fzd8c, zg02, frizzled class receptor 5, frizzled class receptor 5 S homeolog, FZD5, Fzd5, fzd5.S, fzd5
    Hintergrund
    Frizzled-5 (FZD5) is also known as FzE5, which belongs to the G-protein coupled receptor Fz/Smo family. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. FZD5 contains one FZ (frizzled) domain. FZD5 may be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. FZD5 interacts specifically with Wnt5A to induce the beta-catenin pathway. FZD5 interacts with GOPC.
    Molekulargewicht
    42.6 kDa
    UniProt
    Q13467
    Pathways
    WNT Signalweg
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