PKC zeta Protein (Transcript Variant 2) (Myc-DYKDDDDK Tag)

Produktnummer ABIN2729630

Produktdetails

Target: PKC zeta (PRKCZ) (Protein Kinase C, zeta (PRKCZ))

Protein-Typ: Recombinant

Proteineigenschaft: Transcript Variant 2

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses PKC zeta Protein ist gelabelt mit Myc-DYKDDDDK Tag.

Applikation: Antibody Production (AbP), Standard (STD)

Produktmerkmale:

• Recombinant human PRKCZ (transcript variant 2) protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Reinheit: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Anwendungsinformationen

Applikationshinweise: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Kommentare:

The tag is located at the C-terminal.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Lagerung: -80 °C

Informationen zur Lagerung: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Antigendetails

Target: PKC zeta (PRKCZ) (Protein Kinase C, zeta (PRKCZ))

Andere Bezeichnung: Prkcz (PRKCZ Produkte)

Synonyme: TPKC Protein, PKCzeta Protein, prkcz-A Protein, pkc-zeta Protein, PRKCZ Protein, pkc2 Protein, PKC-ZETA Protein, PKC2 Protein, AI098070 Protein, C80388 Protein, Pkcz Protein, R74924 Protein, aPKCzeta Protein, zetaPKC Protein, 14-3-3-zetaisoform Protein, r14-3-3 Protein, pkcz Protein, si:ch211-150o23.4 Protein, protein kinase C zeta L homeolog Protein, protein kinase C zeta Protein, protein kinase C, zeta Protein, prkcz.L Protein, PRKCZ Protein, prkcz Protein, Prkcz Protein

Hintergrund: Protein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a variety of cellular processes such as proliferation, differentiation and secretion. Unlike the classical PKC isoenzymes which are calcium-dependent, PKC zeta exhibits a kinase activity which is independent of calcium and diacylglycerol but not of phosphatidylserine. Furthermore, it is insensitive to typical PKC inhibitors and cannot be activated by phorbol ester. Unlike the classical PKC isoenzymes, it has only a single zinc finger module. These structural and biochemical properties indicate that the zeta subspecies is related to, but distinct from other isoenzymes of PKC. Alternative splicing results in multiple transcript variants encoding different isoforms.

Molekulargewicht: 46.4 kDa

NCBI Accession: NP_001028753

Pathways: NF-kappaB Signalweg, RTK Signalweg, Myometrial Relaxation and Contraction, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Synaptic Membrane, Production of Molecular Mediator of Immune Response, CXCR4-mediated Signaling Events, Thromboxane A2 Receptor Signaling