Telefon:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antikoerper-online.de

c-MYC Protein (Myc Proto-Oncogene protein) (Myc-DYKDDDDK Tag)

MYC Spezies: Human Wirt: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Pubmed (14 Referenzen)
Produktnummer ABIN2715370
$1,112.40
Zzgl. Versandkosten $45.00 und $20.00 Trockeneis
20 μg
Lieferung in 11 Werktagen
  • Target Alle c-MYC (MYC) Proteine anzeigen
    c-MYC (MYC) (Myc Proto-Oncogene protein (MYC))
    Protein-Typ
    Recombinant
    Spezies
    • 7
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Quelle
    • 21
    • 5
    • 2
    • 2
    HEK-293 Cells
    Aufreinigungstag / Konjugat
    Dieses c-MYC Protein ist gelabelt mit Myc-DYKDDDDK Tag.
    Applikation
    Antibody Production (AbP), Standard (STD)
    Produktmerkmale
    • Recombinant human c-Myc protein expressed in HEK293 cells.
    • Produced with end-sequenced ORF clone
    Reinheit
    > 80 % as determined by SDS-PAGE and Coomassie blue staining
  • Applikationshinweise
    Recombinant human proteins can be used for:
    Native antigens for optimized antibody production
    Positive controls in ELISA and other antibody assays
    Kommentare

    The tag is located at the C-terminal.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    50 μg/mL
    Buffer
    25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
    Lagerung
    -80 °C
    Informationen zur Lagerung
    Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
  • Zlatanou, Sabbioneda, Miller, Greenwalt, Aggathanggelou, Maurice, Lehmann, Stankovic, Reverdy, Colland, Vaziri, Stewart: "USP7 is essential for maintaining Rad18 stability and DNA damage tolerance." in: Oncogene, Vol. 35, Issue 8, pp. 965-76, (2016) (PubMed).

    Wanner, Romashko, Werner, May, Peng, Schulz, Foreman, Russo, Arnold, Pingle, Bergstrom, Barany, Thomson: "Reversible linkage of two distinct small molecule inhibitors of Myc generates a dimeric inhibitor with improved potency that is active in myc over-expressing cancer cell lines." in: PLoS ONE, Vol. 10, Issue 4, pp. e0121793, (2015) (PubMed).

    Soufi, Garcia, Jaroszewicz, Osman, Pellegrini, Zaret: "Pioneer transcription factors target partial DNA motifs on nucleosomes to initiate reprogramming." in: Cell, Vol. 161, Issue 3, pp. 555-68, (2015) (PubMed).

    Zhu, Messer, Wang, Lin, Cham, Chang, Billiar, Lotze, Boone, Chang: "Cytosolic HMGB1 controls the cellular autophagy/apoptosis checkpoint during inflammation." in: The Journal of clinical investigation, Vol. 125, Issue 3, pp. 1098-110, (2015) (PubMed).

    Aggarwal, Oddis, Goudeau, Fertig, Metes, Stephens, Qi, Koontz, Levesque: "Anti-signal recognition particle autoantibody ELISA validation and clinical associations." in: Rheumatology (Oxford, England), Vol. 54, Issue 7, pp. 1194-9, (2015) (PubMed).

    Dubey, Singh, Awasthi, Nagarkoti, Kumar, Ali, Chandra, Kumar, Barthwal, Jagavelu, Sánchez-Gómez, Lamas, Dikshit: "L-Plastin S-glutathionylation promotes reduced binding to β-actin and affects neutrophil functions." in: Free radical biology & medicine, Vol. 86, pp. 1-15, (2015) (PubMed).

    Fu, Cheng, Zhang, Mo, Li, Liu, Wang, Pan, Chen, Xue, Ma, Zhang, Han: "The Secreted Form of Transmembrane Protein 98 Promotes the Differentiation of T Helper 1 Cells." in: Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, Vol. 35, Issue 9, pp. 720-33, (2015) (PubMed).

    Choi, Kim, Choi: "Profiles of hypothalamus-pituitary-interrenal axis gene expression in the parr and smolt stages of rainbow trout, Oncorhynchus mykiss: effects of recombinant aquaporin 3 and seawater acclimation." in: Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, Vol. 182, pp. 14-21, (2015) (PubMed).

    Garcia-Sanz, Quintanilla, Lafita, Moreno-Bueno, García-Gutierrez, Tabor, Varela, Shiio, Larsson, Portillo, Leon: "Sin3b interacts with Myc and decreases Myc levels." in: The Journal of biological chemistry, Vol. 289, Issue 32, pp. 22221-36, (2014) (PubMed).

    Brinkmalm, Brinkmalm, Honer, Moreno, Jakobsson, Mallucci, Zetterberg, Blennow, Öhrfelt: "Targeting synaptic pathology with a novel affinity mass spectrometry approach." in: Molecular & cellular proteomics : MCP, Vol. 13, Issue 10, pp. 2584-92, (2014) (PubMed).

    Qiang, Yang, Wu, Zhou, Jacob, Dong, Kuncewitch, Ji, Yang, Wang, Fujita, Nicastro, Coppa, Tracey, Wang: "Cold-inducible RNA-binding protein (CIRP) triggers inflammatory responses in hemorrhagic shock and sepsis." in: Nature medicine, Vol. 19, Issue 11, pp. 1489-95, (2013) (PubMed).

    Groen, Fumoto, Blokhuis, Engelen-Lee, Zhou, van den Heuvel, Koppers, van Diggelen, van Heest, Demmers, Kirby, Shaw, Aronica, Spliet, Veldink, van den Berg, Pasterkamp: "ALS-associated mutations in FUS disrupt the axonal distribution and function of SMN." in: Human molecular genetics, Vol. 22, Issue 18, pp. 3690-704, (2013) (PubMed).

    Porter, Farmaki, Altilia, Schools, West, Chen, Chang, Puzyrev, Lim, Rokow-Kittell, Friedhoff, Papavassiliou, Kalurupalle, Hurteau, Shi, Baran, Gyorffy, Wentland, Broude, Kiaris, Roninson: "Cyclin-dependent kinase 8 mediates chemotherapy-induced tumor-promoting paracrine activities." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, Issue 34, pp. 13799-804, (2012) (PubMed).

    Ye, Gao, Tian, Yearsley, Lange, Robertson, Barsky: "Early to intermediate steps of tumor embolic formation involve specific proteolytic processing of E-cadherin regulated by Rab7." in: Molecular cancer research : MCR, Vol. 10, Issue 6, pp. 713-26, (2012) (PubMed).

  • Target
    c-MYC (MYC) (Myc Proto-Oncogene protein (MYC))
    Andere Bezeichnung
    C-Myc (MYC Produkte)
    Synonyme
    MRTL, MYCC, bHLHe39, c-Myc, CMYC, c-myc, C-MYC, LOC100136746, ARC, B430311C09Rik, MYC, NOP, Nop30, RNCMYC, mMyc, AU016757, Myc2, Niard, Nird, cmyc, zc-myc, c-myc II, myc-B, myc2, CMyc, CG10798, D-Myc, DM, DMYc, Dm, Dmel\CG10798, Dmyc, EG:BACN5I9.1, anon-WO03040301.171, bHLHe57, c-MYC, d-myc, dMYC, dMyc, dMyc1, da, dm, dm/dMyc, dm/myc, dmyc, dmyc1, l(1)G0139, l(1)G0354, l(1)G0359, myc, MYC proto-oncogene, bHLH transcription factor, v-myc myelocytomatosis viral oncogene homolog, nucleolar protein 3 (apoptosis repressor with CARD domain), myelocytomatosis oncogene, MYC proto-oncogene, bHLH transcription factor a, MYC proto-oncogene, bHLH transcription factor L homeolog, v-myc myelocytomatosis viral oncogene homolog (avian), CG10798 gene product from transcript CG10798-RB, MYC, LOC100136746, Nol3, Myc, myca, myc.L
    Hintergrund
    The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene.
    Molekulargewicht
    50.4 kDa
    NCBI Accession
    NP_002458
    Pathways
    p53 Signalweg, Zellzyklus, Sensory Perception of Sound, Transition Metal Ion Homeostasis, Mitotic G1-G1/S Phases, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus
Sie sind hier:
Kundenservice