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c-MYC Protein (Myc Proto-Oncogene protein) (Myc-DYKDDDDK Tag)

MYC Spezies: Human Wirt: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Pubmed (14 Referenzen)
Produktnummer ABIN2715370
Zzgl. Versandkosten $45.00 und $20.00 Trockeneis
20 μg
Lieferung in 11 Werktagen
  • Target Alle c-MYC (MYC) Proteine anzeigen
    c-MYC (MYC) (Myc Proto-Oncogene protein (MYC))
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    • 21
    • 5
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    HEK-293 Cells
    Aufreinigungstag / Konjugat
    Dieses c-MYC Protein ist gelabelt mit Myc-DYKDDDDK Tag.
    Antibody Production (AbP), Standard (STD)
    • Recombinant human c-Myc protein expressed in HEK293 cells.
    • Produced with end-sequenced ORF clone
    > 80 % as determined by SDS-PAGE and Coomassie blue staining
  • Applikationshinweise
    Recombinant human proteins can be used for:
    Native antigens for optimized antibody production
    Positive controls in ELISA and other antibody assays

    The tag is located at the C-terminal.

    Nur für Forschungszwecke einsetzbar
  • Konzentration
    50 μg/mL
    25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
    -80 °C
    Informationen zur Lagerung
    Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
  • Zlatanou, Sabbioneda, Miller, Greenwalt, Aggathanggelou, Maurice, Lehmann, Stankovic, Reverdy, Colland, Vaziri, Stewart: "USP7 is essential for maintaining Rad18 stability and DNA damage tolerance." in: Oncogene, Vol. 35, Issue 8, pp. 965-76, (2016) (PubMed).

    Wanner, Romashko, Werner, May, Peng, Schulz, Foreman, Russo, Arnold, Pingle, Bergstrom, Barany, Thomson: "Reversible linkage of two distinct small molecule inhibitors of Myc generates a dimeric inhibitor with improved potency that is active in myc over-expressing cancer cell lines." in: PLoS ONE, Vol. 10, Issue 4, pp. e0121793, (2015) (PubMed).

    Soufi, Garcia, Jaroszewicz, Osman, Pellegrini, Zaret: "Pioneer transcription factors target partial DNA motifs on nucleosomes to initiate reprogramming." in: Cell, Vol. 161, Issue 3, pp. 555-68, (2015) (PubMed).

    Zhu, Messer, Wang, Lin, Cham, Chang, Billiar, Lotze, Boone, Chang: "Cytosolic HMGB1 controls the cellular autophagy/apoptosis checkpoint during inflammation." in: The Journal of clinical investigation, Vol. 125, Issue 3, pp. 1098-110, (2015) (PubMed).

    Aggarwal, Oddis, Goudeau, Fertig, Metes, Stephens, Qi, Koontz, Levesque: "Anti-signal recognition particle autoantibody ELISA validation and clinical associations." in: Rheumatology (Oxford, England), Vol. 54, Issue 7, pp. 1194-9, (2015) (PubMed).

    Dubey, Singh, Awasthi, Nagarkoti, Kumar, Ali, Chandra, Kumar, Barthwal, Jagavelu, Sánchez-Gómez, Lamas, Dikshit: "L-Plastin S-glutathionylation promotes reduced binding to β-actin and affects neutrophil functions." in: Free radical biology & medicine, Vol. 86, pp. 1-15, (2015) (PubMed).

    Fu, Cheng, Zhang, Mo, Li, Liu, Wang, Pan, Chen, Xue, Ma, Zhang, Han: "The Secreted Form of Transmembrane Protein 98 Promotes the Differentiation of T Helper 1 Cells." in: Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, Vol. 35, Issue 9, pp. 720-33, (2015) (PubMed).

    Choi, Kim, Choi: "Profiles of hypothalamus-pituitary-interrenal axis gene expression in the parr and smolt stages of rainbow trout, Oncorhynchus mykiss: effects of recombinant aquaporin 3 and seawater acclimation." in: Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, Vol. 182, pp. 14-21, (2015) (PubMed).

    Garcia-Sanz, Quintanilla, Lafita, Moreno-Bueno, García-Gutierrez, Tabor, Varela, Shiio, Larsson, Portillo, Leon: "Sin3b interacts with Myc and decreases Myc levels." in: The Journal of biological chemistry, Vol. 289, Issue 32, pp. 22221-36, (2014) (PubMed).

    Brinkmalm, Brinkmalm, Honer, Moreno, Jakobsson, Mallucci, Zetterberg, Blennow, Öhrfelt: "Targeting synaptic pathology with a novel affinity mass spectrometry approach." in: Molecular & cellular proteomics : MCP, Vol. 13, Issue 10, pp. 2584-92, (2014) (PubMed).

    Qiang, Yang, Wu, Zhou, Jacob, Dong, Kuncewitch, Ji, Yang, Wang, Fujita, Nicastro, Coppa, Tracey, Wang: "Cold-inducible RNA-binding protein (CIRP) triggers inflammatory responses in hemorrhagic shock and sepsis." in: Nature medicine, Vol. 19, Issue 11, pp. 1489-95, (2013) (PubMed).

    Groen, Fumoto, Blokhuis, Engelen-Lee, Zhou, van den Heuvel, Koppers, van Diggelen, van Heest, Demmers, Kirby, Shaw, Aronica, Spliet, Veldink, van den Berg, Pasterkamp: "ALS-associated mutations in FUS disrupt the axonal distribution and function of SMN." in: Human molecular genetics, Vol. 22, Issue 18, pp. 3690-704, (2013) (PubMed).

    Porter, Farmaki, Altilia, Schools, West, Chen, Chang, Puzyrev, Lim, Rokow-Kittell, Friedhoff, Papavassiliou, Kalurupalle, Hurteau, Shi, Baran, Gyorffy, Wentland, Broude, Kiaris, Roninson: "Cyclin-dependent kinase 8 mediates chemotherapy-induced tumor-promoting paracrine activities." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, Issue 34, pp. 13799-804, (2012) (PubMed).

    Ye, Gao, Tian, Yearsley, Lange, Robertson, Barsky: "Early to intermediate steps of tumor embolic formation involve specific proteolytic processing of E-cadherin regulated by Rab7." in: Molecular cancer research : MCR, Vol. 10, Issue 6, pp. 713-26, (2012) (PubMed).

  • Target
    c-MYC (MYC) (Myc Proto-Oncogene protein (MYC))
    Andere Bezeichnung
    C-Myc (MYC Produkte)
    MRTL, MYCC, bHLHe39, c-Myc, CMYC, c-myc, C-MYC, LOC100136746, ARC, B430311C09Rik, MYC, NOP, Nop30, RNCMYC, mMyc, AU016757, Myc2, Niard, Nird, cmyc, zc-myc, c-myc II, myc-B, myc2, CMyc, CG10798, D-Myc, DM, DMYc, Dm, Dmel\CG10798, Dmyc, EG:BACN5I9.1, anon-WO03040301.171, bHLHe57, c-MYC, d-myc, dMYC, dMyc, dMyc1, da, dm, dm/dMyc, dm/myc, dmyc, dmyc1, l(1)G0139, l(1)G0354, l(1)G0359, myc, MYC proto-oncogene, bHLH transcription factor, v-myc myelocytomatosis viral oncogene homolog, nucleolar protein 3 (apoptosis repressor with CARD domain), myelocytomatosis oncogene, MYC proto-oncogene, bHLH transcription factor a, MYC proto-oncogene, bHLH transcription factor L homeolog, v-myc myelocytomatosis viral oncogene homolog (avian), CG10798 gene product from transcript CG10798-RB, MYC, LOC100136746, Nol3, Myc, myca, myc.L
    The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene.
    50.4 kDa
    NCBI Accession
    p53 Signalweg, Zellzyklus, Sensory Perception of Sound, Transition Metal Ion Homeostasis, Mitotic G1-G1/S Phases, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus
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