BIN1 Protein (Transcript Variant 2) (Myc-DYKDDDDK Tag)

Produktnummer ABIN2715269

Produktdetails

Target: BIN1 (Bridging Integrator 1 (BIN1))

Protein-Typ: Recombinant

Proteineigenschaft: Transcript Variant 2

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses BIN1 Protein ist gelabelt mit Myc-DYKDDDDK Tag.

Applikation: Antibody Production (AbP), Standard (STD)

Produktmerkmale:

• Recombinant human BIN1 / AMPHL (transcript variant 2) protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Reinheit: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Anwendungsinformationen

Applikationshinweise: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Kommentare:

The tag is located at the C-terminal.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Lagerung: -80 °C

Informationen zur Lagerung: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Antigendetails

Target: BIN1 (Bridging Integrator 1 (BIN1))

Andere Bezeichnung: Bin1,amphl (BIN1 Produkte)

Synonyme: bin1 Protein, MGC53185 Protein, amph2 Protein, amphl Protein, sh3p9 Protein, MGC76187 Protein, cb57 Protein, zgc:86701 Protein, BIN1 Protein, AMPH2 Protein, AMPHL Protein, SH3P9 Protein, ALP-1 Protein, Amphl Protein, BRAMP-2 Protein, bridging integrator 1 Protein, bridging integrator 1 S homeolog Protein, bridging integrator 1b Protein, BIN1 Protein, bin1.S Protein, bin1 Protein, bin1b Protein, Bin1 Protein

Hintergrund: This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in several transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described.

Molekulargewicht: 59.8 kDa

NCBI Accession: NP_647594