IL4 Receptor Protein (Transcript Variant 1)
Kurzübersicht für IL4 Receptor Protein (Transcript Variant 1) (ABIN2713396)
Target
Alle IL4 Receptor (IL4R) Proteine anzeigenProtein-Typ
Biologische Aktivität
Spezies
Quelle
Applikation
Reinheit
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Proteineigenschaft
- Transcript Variant 1
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Spezifität
- Optimal preservation of protein structure, post-translational modifications and functions.
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Produktmerkmale
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- Recombinant human CD124 / IL4R (transcript variant 1) protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
- Tested for bioactivity.
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Endotoxin-Niveau
- Endotoxin level is <0.1 ng/μg of protein (<1EU/μg).
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Biological Activity Comment
- ED50 was determined by its ability to inhibit the IL-4 dependent proliferation of human TF-1 cells is less than or equal to 5.0 ng/ml (in the presence of 0.5 ng/ml of IL-4), corresponding to a specific activity of > 2 x 10^5 units/mg.
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Applikationshinweise
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays
Protein-protein interaction
In vitro biochemical assays and cell-based functional assays -
Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Buffer
- Lyophilized from a 0.2 μM filtered solution of 20 mM phosphate buffer,100 mM NaCl, pH 7.2
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Handhabung
- Resuspend the protein in the desired concentration in proper buffer
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Lagerung
- -80 °C
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Informationen zur Lagerung
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- IL4 Receptor (IL4R) (Interleukin 4 Receptor (IL4R))
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Andere Bezeichnung
- Cd124,il4r
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Hintergrund
- This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants.
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Molekulargewicht
- 24 kDa
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NCBI Accession
- NP_000409
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Pathways
- JAK-STAT Signalweg, Positive Regulation of Immune Effector Process
Target
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