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IL4 Receptor Protein (Transcript Variant 1)

Dieses Recombinant IL4 Receptor-Protein wird in HEK-293 Cells exprimiert.
Produktnummer ABIN2713396

Kurzübersicht für IL4 Receptor Protein (Transcript Variant 1) (ABIN2713396)

Target

Alle IL4 Receptor (IL4R) Proteine anzeigen
IL4 Receptor (IL4R) (Interleukin 4 Receptor (IL4R))

Protein-Typ

Recombinant

Biologische Aktivität

Active

Spezies

  • 21
  • 9
  • 7
  • 5
  • 4
  • 1
Human

Quelle

  • 23
  • 6
  • 5
  • 2
  • 2
  • 2
  • 1
  • 1
HEK-293 Cells

Applikation

Functional Studies (Func), Antibody Production (AbP), Protein Interaction (PI), Standard (STD)

Reinheit

> 95 % as determined by SDS-PAGE and Coomassie blue staining
  • Proteineigenschaft

    Transcript Variant 1

    Spezifität

    Optimal preservation of protein structure, post-translational modifications and functions.

    Produktmerkmale

    • Recombinant human CD124 / IL4R (transcript variant 1) protein expressed in HEK293 cells.
    • Produced with end-sequenced ORF clone
    • Tested for bioactivity.

    Endotoxin-Niveau

    Endotoxin level is <0.1 ng/μg of protein (<1EU/μg).

    Biological Activity Comment

    ED50 was determined by its ability to inhibit the IL-4 dependent proliferation of human TF-1 cells is less than or equal to 5.0 ng/ml (in the presence of 0.5 ng/ml of IL-4), corresponding to a specific activity of > 2 x 10^5 units/mg.
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  • Applikationshinweise

    Recombinant human proteins can be used for:
    Native antigens for optimized antibody production
    Positive controls in ELISA and other antibody assays
    Protein-protein interaction
    In vitro biochemical assays and cell-based functional assays

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Buffer

    Lyophilized from a 0.2 μM filtered solution of 20 mM phosphate buffer,100 mM NaCl, pH 7.2

    Handhabung

    Resuspend the protein in the desired concentration in proper buffer

    Lagerung

    -80 °C

    Informationen zur Lagerung

    Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
  • Target

    IL4 Receptor (IL4R) (Interleukin 4 Receptor (IL4R))

    Andere Bezeichnung

    Cd124,il4r

    Hintergrund

    This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants.

    Molekulargewicht

    24 kDa

    NCBI Accession

    NP_000409

    Pathways

    JAK-STAT Signalweg, Positive Regulation of Immune Effector Process
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